PAR-3 Inhibitors
PAR-3 inhibitors belong to a distinctive chemical class within the realm of molecular compounds, exerting their influence on cellular processes through the regulation of a protein known as PAR-3, or Partitioning-defective 3. PAR-3, in turn, is a crucial component of the PAR (Partitioning-defective) protein complex, which plays pivotal roles in diverse cellular functions, particularly those related to cell polarity, cell adhesion, and intracellular trafficking. These inhibitors are designed to modulate the activity of PAR-3, often by impeding its interaction with other proteins or signaling pathways.
At a molecular level, PAR-3 inhibitors are typically small molecules or peptides that disrupt the intricate interactions between PAR-3 and its binding partners, thereby influencing cellular behaviors. The PAR-3 protein is particularly renowned for its role in establishing and maintaining cell polarity, a fundamental process that is crucial for embryonic development, tissue organization, and various physiological functions. By interfering with PAR-3, these inhibitors can disrupt the proper localization of cellular components, leading to alterations in cell shape, motility, and adhesion. Furthermore, they may impact the regulation of intracellular trafficking pathways, influencing the movement of vesicles and organelles within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $113.00 $423.00 | ||
PF-477736 is a potent inhibitor of PAR-3, acting on Chk1 to block cell cycle progression and induce apoptosis in cancer cells. It hinders the repair of DNA damage, making it a potential anti-cancer agent. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
MK-8776 is a Chk1 inhibitor that interferes with PAR-3 by preventing cell cycle checkpoint activation and DNA repair. This disruption can lead to the selective killing of cancer cells. | ||||||
LY2606368 | 1234015-52-1 | sc-507521 sc-507521A sc-507521B sc-507521C sc-507521D sc-507521E | 5 mg 10 mg 25 mg 100 mg 1 g 10 g | $176.00 $300.00 $500.00 $1900.00 $8000.00 $25000.00 | ||
LY2606368 is a Chk1 inhibitor that impairs PAR-3 by disrupting the cell cycle and DNA damage repair processes in cancer cells. It can induce apoptosis and enhance the effectiveness of chemotherapy. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $246.00 | 10 | |
UCN-01 (7-Hydroxystaurosporine) is a broad-spectrum kinase inhibitor that affects PAR-3 by inhibiting Chk1 and other kinases involved in cell cycle regulation and DNA repair. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is a selective inhibitor of the ATR kinase, which plays a role in the DNA damage response. By inhibiting ATR, VE-821 affects PAR-3 by disrupting cell cycle checkpoints and DNA repair processes. | ||||||