PAPD1 Activators
PAPD1 activators are a class of chemical compounds that specifically interact with and modulate the activity of the enzyme poly(A) polymerase delta 1, commonly abbreviated as PAPD1 or TENT4A. This enzyme plays a crucial role in the post-transcriptional modification of RNA molecules. PAPD1 is involved in the process known as polyadenylation, where a poly(A) tail is added to the 3' end of an RNA molecule. The addition of the poly(A) tail is a significant step in the maturation of messenger RNA (mRNA) precursors into functional mRNA, which is subsequently utilized by the cell's machinery to synthesize proteins. The poly(A) tail also has important implications in the stability and transportation of the mRNA molecule within the cell. PAPD1 is not the only enzyme capable of polyadenylation; however, it is distinct in its specific functions and interactions with other molecular components within the cellular milieu.
Chemical activators of PAPD1, therefore, interact with this enzyme to modulate its activity, potentially altering the rate or specificity of the polyadenylation process. These molecules can bind to various domains of PAPD1, influencing its catalytic activity, altering substrate specificity, or affecting its interaction with other proteins and RNA molecules. The design of such compounds requires a deep understanding of the enzyme's structure and the dynamics of its active site. The modulation of PAPD1 activity by these activators may affect the overall gene expression profile of a cell by changing the landscape of mRNA molecules that are available for translation, impacting the cellular proteome. The precise mechanisms by which PAPD1 activators exert their effects are subject to ongoing research, aiming to elucidate the intricate details of RNA processing and the regulation of gene expression at the post-transcriptional level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) within cells. Elevated cAMP levels can enhance the activity of PAPD1 by promoting cellular processes that PAPD1 is involved in, including the regulation of RNA polyadenylation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which breaks down cAMP. By inhibiting PDE4 and thus preventing cAMP degradation, rolipram indirectly increases cAMP levels, which may enhance PAPD1 activity in pathways where cAMP is a secondary messenger. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. This can indirectly enhance PAPD1's activity by stabilizing cellular environments where cAMP-mediated signaling is essential for PAPD1 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to upregulate the cAMP signaling pathway by modulating the activity of adenylate cyclase. This action can indirectly increase PAPD1 activity, as cAMP signaling is often involved in processes that PAPD1 regulates. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea that has been reported to affect multiple signaling pathways. While its direct impact on PAPD1 is not established, it can influence pathways where PAPD1 may be indirectly activated, such as those involved in cellular stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate sirtuin proteins, which are involved in cellular stress responses. By modulating sirtuin activity, resveratrol can indirectly influence cellular processes that PAPD1 is part of, thus potentially enhancing PAPD1 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Db-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it can indirectly enhance the activity of PAPD1 by engaging with the same signaling pathways that PAPD1 is involved in. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit glycogen synthase kinase-3 (GSK-3). While the direct relationship to PAPD1 is not established, inhibition of GSK-3 can affect Wnt signaling, which might intersect with pathways involving PAPD1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that modulates various signaling pathways, including those involved in anti-inflammatory responses. By influencing these pathways, quercetin could indirectly enhance PAPD1 activity related to RNA processing in response to cellular stress. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinase (SAPK) pathways. By activating these pathways, anisomycin may lead to indirect enhancement of PAPD1 activity if PAPD1 is involved in the cellular stress response. | ||||||