PAK5 Inhibitors

PAK5 inhibitors, as listed, are primarily broader PAK inhibitors or target other kinases and signaling pathways that could indirectly influence PAK5 activity. The PAK family is divided into Group I (PAK1, PAK2, PAK3) and Group II (PAK4, PAK5, PAK6), and inhibitors often show cross-reactivity within these groups due to structural similarities.

Compounds like FRAX597 and IPA-3 are more selective for Group I PAKs but may exhibit some degree of cross-kinase activity affecting PAK5. G-5555 is a more direct approach, being a selective Group II PAK inhibitor, thus targeting PAK5 more specifically. KPT-9274 and PF-03758309, though initially designed to inhibit PAK4, may also affect PAK5 due to the close kinship in the PAK family. Other inhibitors, such as AZ13705339 and Celecoxib, initially targeting different kinases or pathways, may have off-target effects on PAK5. Inhibitors like HS-173 and Dasatinib work through broader kinase inhibition or modulating signaling pathways, potentially impacting PAK5 indirectly.