p47 Activators
The protein p47 plays a pivotal role in cellular physiology, functioning as a key regulator in the orchestration of vesicular trafficking, autophagy, and cytoskeletal dynamics. This multifunctionality underscores p47's importance in maintaining cellular integrity, facilitating the precise delivery of vesicles to their intended destinations, and ensuring the effective degradation and recycling of cellular components through autophagy. The protein's involvement in cytoskeletal organization further highlights its critical role in maintaining cell shape, enabling motility, and ensuring the correct partitioning of cellular contents during cell division. Through these actions, p47 is deeply integrated into the cellular response to environmental stimuli, stress, and developmental cues, acting as a linchpin in the cellular machinery that governs cell survival, adaptation, and function.
Activation mechanisms of p47 are complex and nuanced, involving a sophisticated interplay of signaling pathways that ensure its function is precisely modulated in response to cellular needs. Activation of p47 is not a straightforward process; rather, it involves indirect pathways that enhance its functional state. This involves the modulation of upstream signaling molecules and pathways that, in turn, influence p47 activity. For example, the elevation of intracellular second messengers such as cyclic AMP (cAMP) and cyclic GMP (cGMP), through the action of various signaling molecules, can initiate a cascade of phosphorylation events mediated by kinases such as protein kinase A (PKA) and protein kinase G (PKG). These events can lead to the phosphorylation of p47, which may alter its conformation, localization, or interaction with other proteins, thereby modulating its activity. Furthermore, the modulation of cellular redox states, through the action of antioxidants or the regulation of calcium influx via specific ion channels, can also impact p47 activity, linking cellular metabolic states to its activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP levels can enhance the activation of cAMP-dependent protein kinase A (PKA), which in turn, may phosphorylate and activate p47, facilitating its role in cellular processes such as vesicle trafficking and cytoskeletal organization. | ||||||
Leukotriene B4-d4 | 124629-74-9 | sc-221844 sc-221844A | 25 µg 50 µg | $256.00 $651.00 | ||
A lipid mediator that can trigger p47phox activation and ROS production. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a nonspecific inhibitor of phosphodiesterases, prevents the breakdown of cAMP and cGMP, thereby sustaining their levels within the cell. This elevation in cAMP and cGMP can indirectly activate PKA and PKG pathways respectively, which might lead to the phosphorylation and activation of p47, enhancing its cellular functions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has been shown to influence various signaling pathways, including those involving NF-kB and ROS, which could indirectly lead to the activation of p47 by modulating cellular redox states and inflammatory responses, potentially enhancing p47's role in autophagy and immune response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to modulate multiple signaling pathways, including those related to NF-kB, Wnt/β-catenin, and JAK/STAT. Through these pathways, curcumin can promote the activation of transcription factors and kinases that may lead to the activation of p47, particularly in pathways related to inflammation and cellular stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, influencing cellular processes such as aging and inflammation. Through SIRT1 activation, resveratrol may indirectly activate p47 by improving mitochondrial function and enhancing cellular resistance to oxidative stress, which are processes where p47 is involved. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram, a selective inhibitor of phosphodiesterase 4 (PDE4), elevates intracellular cAMP levels by preventing its breakdown. Increased cAMP levels can activate PKA, which may phosphorylate and activate p47, potentially influencing its involvement in cellular signaling and vesicle trafficking. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates transient receptor potential vanilloid 1 (TRPV1) channels, leading to Ca2+ influx. The increase in intracellular Ca2+ can activate calcium-dependent signaling pathways that may phosphorylate and activate p47, playing a role in sensory neuron functions and inflammatory processes. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, a phosphodiesterase inhibitor, increases cAMP levels by inhibiting its breakdown. This elevation can enhance PKA activity, which in turn, could phosphorylate and activate p47, potentially influencing its role in modulating energy metabolism and cellular response to stress. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, has been shown to modulate various signaling pathways, including kinase and phosphatase activities. Through these actions, quercetin may indirectly activate p47 by influencing pathways related to antioxidant defense and inflammation. | ||||||