p41-ARCb Activators
The chemicals that are classified as p41-ARCb Activators are primarily involved in influencing actin dynamics, as p41-ARCb is a key component of the Arp2/3 complex that is integral to actin polymerization. The chemicals can enhance the functional activity of p41-ARCb via direct or indirect mechanisms. For example, Jasplakinolide directly induces actin polymerization by binding to F-actin and stabilizing it, thereby enhancing the function of the p41-ARCb. Similarly, Latrunculin A and Swinholide A indirectly enhance the function of p41-ARCb by increasing the concentration of G-actin, which drives the Arp2/3 complex-mediated actin polymerization.
Other chemicals, such as Neomycin and Phosphatidylinositol 4,5-bisphosphate (PIP2), influence PIP2 metabolism, a key factor in the regulation of actin polymerization. The hydrolysis of PIP2 by phospholipase C leads to the formation of inositol trisphosphate and diacylglycerol, both of which are crucial for the activation of actin polymerization. Additionally, inhibitors of protein phosphatases like Calyculin A and Okadaic acid, and inhibitors of Rho-associated coiled-coil containing protein kinase like Y-27632, can alter the phosphorylation state of actin regulatory proteins, indirectly influencing the activity of p41-ARCb. The bioactive lipid Prostaglandin E2 also has a potential role in enhancing the activity of p41-ARCb by impacting actin dynamics through the activation of EP2 and EP4 receptors. These chemicals, by virtue of their specific biochemical actions, can enhance the functional activity of p41-ARCb by directly or indirectly influencing the actin polymerization process.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is a marine sponge metabolite that acts as a potent inducer of actin polymerization. It binds to F-actin, stabilizing it and enhancing its polymerization, thus enhancing the action of proteins like p41-ARCb that are involved in the process. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is an actin depolymerizing agent. It binds to G-actin, preventing it from polymerizing into F-actin. This elevates the concentration of G-actin, which can induce the Arp2/3 complex to initiate actin polymerization, enhancing the function of p41-ARCb. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin is an aminoglycoside antibiotic that has been shown to affect PIP2 metabolism. It can inhibit the interaction of proteins with PIP2, thereby affecting the regulation of actin polymerization, a process that p41-ARCb is involved in. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is a cell-permeable fungal toxin that inhibits actin polymerization. While it primarily acts as an inhibitor, this inhibition leads to the accumulation of actin monomers, which could trigger the Arp2/3 complex to initiate actin polymerization, indirectly enhancing the function of p41-ARCb. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A is a marine metabolite that induces actin depolymerization. It severs actin filaments, thereby increasing the concentration of G-actin, which can drive Arp2/3 complex-mediated actin polymerization, enhancing the activity of p41-ARCb. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is a cell-permeable, selective inhibitor of the Neural Wiskott-Aldrich syndrome protein (N-WASP), a key regulator of Arp2/3 complex. By inhibiting N-WASP, Wiskostatin can indirectly influence the activity of p41-ARCb. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium ionophore A23187 is a mobile ion carrier that transports Ca2+ across cell membranes. Changes in intracellular calcium levels can affect actin dynamics, potentially enhancing the activity of the Arp2/3 complex and p41-ARCb. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. It can influence actin dynamics by altering the phosphorylation state of actin regulatory proteins, thereby influencing the activity of p41-ARCb in the Arp2/3 complex. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, similar to calyculin A. It can influence actin dynamics by altering the phosphorylation state of actin regulatory proteins, thereby influencing the activity of p41-ARCb. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated coiled-coil containing protein kinase). Rho signaling is involved in the regulation of actin dynamics, and by inhibiting ROCK, Y-27632 can influence the actin polymerization process, potentially enhancing the activity of p41-ARCb. | ||||||