Molecular structure of Neomycin sulfate, CAS Number: 1405-10-3
Neomycin sulfate (CAS 1405-10-3)
See product citations (20)
Alternate Names:
Neomycin B sulfate
Application:
Neomycin sulfate is a highly active antibiotic against gram-negative bacteria often used in cell culture
CAS Number:
1405-10-3
Molecular Weight:
908.88
Molecular Formula:
C23H46N6O13•3H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.
Neomycin sulfate (CAS 1405-10-3) References
- DNase I induced DNA degradation is inhibited by neomycin. | Woegerbauer, M., et al. 2000. J Antibiot (Tokyo). 53: 276-85. PMID: 10819299
- Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. | Liscovitch, M., et al. 1991. Biochem J. 279 (Pt 1): 319-21. PMID: 1930152
- Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2). | Gabev, E., et al. 1989. Biochim Biophys Acta. 979: 105-12. PMID: 2537103
- Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect. | Choi, JS., et al. 2016. Drug Deliv. 23: 2806-2812. PMID: 26394193
- Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments. | Blanchard, C., et al. 2016. Antimicrob Agents Chemother. 60: 862-72. PMID: 26596945
- Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. | Carney, DH., et al. 1985. Cell. 42: 479-88. PMID: 2992800
- Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle. | Vergara, J., et al. 1985. Proc Natl Acad Sci U S A. 82: 6352-6. PMID: 2994073
- Monitoring of neomycin sulfate antibiotic in microbial fuel cells. | Catal, T., et al. 2018. Bioresour Technol. 268: 116-120. PMID: 30077167
- Neomycin is a potent agent for arachidonic acid release in human platelets. | Nakashima, S., et al. 1987. Biochem Biophys Res Commun. 146: 820-6. PMID: 3113426
- Colorimetric detection of neomycin sulfate in tilapia based on plasmonic core-shell Au@PVP nanoparticles. | Zhang, Q., et al. 2021. Food Chem. 356: 129612. PMID: 33831828
- Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine. | Liu, Y., et al. 2021. J Vet Pharmacol Ther. 44: 850-853. PMID: 34165196
- Effects of neomycin on calcium and polyphosphoinositide metabolism of guinea pig synaptosomes. | Griffin, HD., et al. 1980. J Neurochem. 34: 750-2. PMID: 6243700
- In vitro interactions of neomycin sulfate, bacitracin, and polymyxin B sulfate. | Booth, JH., et al. 1994. Int J Dermatol. 33: 517-20. PMID: 7928043
Inhibitor of:
α Enolase, γ Enolase, AARS2, Aminopeptidase P1, Annexin A9, Annexin IV, AP1S2, APXL, Calcium Channel Protein, CAT56, CHMP7, COPD, copine 9, CstF-50, DFNB59, DSCAML1, EG628456, endobrevin, Gβ 5, GOLGA6B, GOLGA6L9, group IVD sPLA2, H2-M10.5, H2-Q6, INPP5B, ITPK1, LOC100040299, LOC100040722, LOC100041119, LOC645485, MARS2, MRP-S22, Nir1, NYNRIN, OCRL, opticin, OR5B3, OR5M3, ORP-7_Osbpl7, PABP, PABPC2, PABPC3, PABPC6, PC-PLD2, PIEZO1, PITP, PITPNC1, PLC, PLC β2, PLC δ3, PLC ε, PLC ε2, PLC η1, PLC η2, PLC ζ, PLC 2, PLC-L, PLC-XD1, PLCδ1, PLEKHS1, PLP-Cα, PLP-Cβ, PLP-Cδ, PPAPDC2, Rab 19, RAb 19B, rabphilin-3AL, RBMY1, reticulocalbin-3, Ribosomal Protein L29, Ribosomal Protein L39, Ribosomal Protein LP1, Ribosomal Protein S17, Ribosomal Protein S5, Ribosomal Protein S7, RNH1, RPL24, Salmonella (Enterobacterales), Salmonella paratyphi 0-2, SCP-2, Sec4, SH3TC1, Shigatoxin 2, SKIP, Slac2-c, SYAP1, Synaptojanin 2, Synaptotagmin XI, TaR, TBC1D2B, TMEM55A, TRUB2, and TYW4.Activator of:
4.1R, ARHGEF39, CapZ-α1, CHMP4A, COPG, CR16, DANGER, DAP-4, EFR3A, epsin, GPR171, GRASP, IF3, ITPK1, LYPD4, Myosin-15, Nephrocalcin, NIPA1, OCM, OR51M1, Otolin-1, p41-ARCb, PIP5KIII, PIPK I γ, PITPNC1, PLC δ4, PLC-L, PLC-XD1, Rab 37, Rab 39B, Rab 3D, Rab GDI β, Raver1, Ribosomal Protein L18, SNX15, Swiprosin-1, Synaptojanin 1, Synaptotagmin X, t-SNARE 1, Type I 5-phosphatase, and WWC2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neomycin sulfate, 1 g | sc-3573 | 1 g | $27.00 | |||
Neomycin sulfate, 5 g | sc-3573A | 5 g | $35.00 |