OTUD7A Activators
OTUD7A activators belong to a class of compounds that modulate the activity of the OTUD7A enzyme, a member of the ovarian tumor deubiquitinase (OTU) family of proteases. Specifically, this enzyme functions within the cellular machinery to cleave ubiquitin or ubiquitin-like protein modifications from target proteins. Ubiquitination is a reversible post-translational modification that affects various cellular processes, including protein degradation, cell cycle regulation, DNA repair, and signal transduction. OTUD7A's role as a deubiquitinating enzyme (DUB) is crucial in maintaining the balance of protein ubiquitination, thereby ensuring proper cellular function and homeostasis. Activators of OTUD7A enhance the enzyme's deubiquitination activity, which can influence the ubiquitin-proteasome system and ubiquitin-dependent signaling pathways.
The study of OTUD7A activators is grounded in the intricate biochemistry of protein regulation. The ability to activate OTUD7A can influence the dynamics of ubiquitin-dependent pathways, which is of high interest in the realm of cellular biology. These activators are typically small molecules that bind to the OTUD7A enzyme, stabilizing it in an active conformation or enhancing its interaction with substrate proteins. This interaction can lead to increased deubiquitination activity, which in turn can affect the stability and function of proteins that are normally regulated by ubiquitination. The specificity and mode of action of OTUD7A activators are subjects of intensive research, aimed at understanding the underlying mechanisms by which these molecules exert their biochemical effects. Through such studies, the role of OTUD7A in cellular processes is further elucidated, contributing to the broader understanding of protein regulation via ubiquitination and deubiquitination.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can indirectly enhance OTUD7A activity by promoting signaling pathways that OTUD7A is involved in, such as immune response modulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which could influence signaling pathways that affect OTUD7A's functional activity by modulating immune signaling pathways where OTUD7A plays a role. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, potentially enhancing OTUD7A's activity by altering calcium-dependent signaling mechanisms that OTUD7A is associated with. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate modulates sphingolipid signaling pathways that can indirectly enhance OTUD7A activity, as OTUD7A is involved in complex cellular processes, including cell survival and proliferation. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is a PI3K inhibitor that could alter signaling pathways to indirectly increase OTUD7A activity by affecting signaling cascades that OTUD7A may influence, particularly in immune regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can indirectly increase OTUD7A activity by raising intracellular calcium and activating calcium-dependent signaling pathways that OTUD7A is a part of. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can indirectly enhance OTUD7A's functional activity by modulating pathways involved in cell survival where OTUD7A might have a regulatory role. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which can shift signaling towards pathways that OTUD7A is involved in, potentially enhancing its activity in processes such as protein ubiquitination. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, which could enhance OTUD7A's activity by impacting related signaling pathways. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits the Hedgehog signaling pathway, which could redirect signaling to pathways that OTUD7A is involved in, thus potentially enhancing its activity. | ||||||