OTUD1 Activators
OTUD1 activators belong to a distinctive class of chemical compounds that exert their biological effects through modulation of the OTUD1 enzyme. OTUD1, or ovarian tumor domain-containing deubiquitinase 1, is a deubiquitinase enzyme that plays a crucial role in cellular processes by selectively removing ubiquitin moieties from target proteins. Ubiquitination is a post-translational modification that regulates protein stability, localization, and activity within the cell. The modulation of OTUD1 activity through these activators represents a novel approach in the realm of cellular signaling and protein homeostasis.
The chemical entities classified as OTUD1 activators typically possess a unique structural scaffold that allows them to interact with the active site of OTUD1, thereby influencing its catalytic activity. By selectively enhancing the deubiquitinating function of OTUD1, these activators contribute to the dynamic regulation of ubiquitin-dependent pathways. This fine-tuned control over protein ubiquitination holds promise for influencing various cellular processes, including DNA repair, immune response, and cell cycle progression. Further research into the specific mechanisms and downstream effects of OTUD1 activation will likely unveil the full spectrum of cellular events that can be modulated by this distinct class of chemical compounds, paving the way for a deeper understanding of cellular signaling networks and potential implications in various biological contexts.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. OTUD1 is known to interact with PKA, which is activated by cAMP. Therefore, by increasing cAMP levels, Forskolin can indirectly enhance the functional activity of OTUD1. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is a selective proteasome inhibitor, which can lead to the accumulation of ubiquitinated proteins. As OTUD1 is a deubiquitinating enzyme, inhibiting the proteasome can indirectly enhance its functional activity by increasing the substrate availability for OTUD1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is another proteasome inhibitor. Similar to Epoxomicin, it can increase the availability of ubiquitinated proteins, thereby indirectly enhancing the functional activity of OTUD1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K/Akt pathway has been implicated in the regulation of OTUD1. Hence, by inhibiting PI3K, LY294002 can indirectly enhance the functional activity of OTUD1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, it can indirectly enhance the functional activity of OTUD1 by modulating the PI3K/Akt pathway. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it can increase the level of phosphorylated proteins, which may indirectly enhance the functional activity of OTUD1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is another potent inhibitor of protein phosphatases 1 and 2A. Like Calyculin A, it can indirectly enhance the functional activity of OTUD1 by increasing the level of phosphorylated proteins. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. By inhibiting various kinases, it can modulate multiple signaling pathways that involve OTUD1, hence indirectly enhancing its functional activity. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB202190 is a p38 MAPK inhibitor, and p38 MAPK has been reported to interact with OTUD1. Therefore, SB202190 can indirectly enhance the functional activity of OTUD1 by modulating the p38 MAPK pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. As JNK is a known interaction partner of OTUD1, this inhibitor can indirectly enhance the functional activity of OTUD1 by influencing the JNK pathway. | ||||||