OTTMUSG00000016694 Activators
Ferritin, heavy polypeptide-like 17-like 3 (Fthl17d) is a member of the ferritin protein family, which plays a crucial role in cellular iron homeostasis. Fthl17d, like other ferritin proteins, serves as an iron storage molecule within cells, preventing iron-induced oxidative damage and maintaining iron balance. It achieves this by forming a protein complex capable of sequestering and storing excess iron ions in a safe and bioavailable form.
Activation of Fthl17d primarily depends on the availability of iron ions within the cellular environment. Iron(II) sulfate and ferrous chloride directly activate Fthl17d by providing ferrous ions, which can be bound and stored within the ferritin complex. This enhances the protein's iron-sequestering function. Furthermore, compounds like N-Acetylcysteine indirectly activate Fthl17d by supporting the availability of cysteine, a critical component of ferritin, which is necessary for its iron-binding activity. Fthl17d activation is tightly linked to cellular iron levels and relies on the proper functioning of iron-related pathways. Understanding the activation mechanisms of Fthl17d is essential for comprehending the regulation of intracellular iron storage and its impact on overall cellular hea
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $73.00 $109.00 | ||
Iron(II) sulfate directly activates the protein by providing the necessary iron ions for ferritin to store, promoting its function in iron sequestration. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine indirectly activates the protein by increasing the availability of cysteine, a component of ferritin, thereby supporting its iron-binding activity. | ||||||
Iron(II) chloride | 7758-94-3 | sc-252912 | 100 g | $265.00 | ||
Ferrous chloride directly activates ferritin by providing ferrous ions that can be incorporated into the ferritin complex, enhancing its iron storage capacity. | ||||||
Hemin chloride | 16009-13-5 | sc-202646 sc-202646A sc-202646B | 5 g 10 g 25 g | $102.00 $160.00 $326.00 | 9 | |
Hemin activates ferritin indirectly by inducing heme oxygenase-1 (HO-1) expression, leading to the release of iron from heme molecules and subsequent ferritin loading. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Vitamin C indirectly activates ferritin by enhancing iron absorption in the intestines, increasing the availability of iron for ferritin storage in cells. | ||||||
Iron(III) chloride | 7705-08-0 | sc-215192 sc-215192A sc-215192B | 10 g 100 g 500 g | $41.00 $46.00 $87.00 | ||
Ferric chloride directly activates ferritin by providing ferric ions that can be bound and stored by the ferritin protein complex, promoting its iron-sequestering function. | ||||||
Iron(III) citrate | 3522-50-7 | sc-286019 sc-286019A | 100 g 250 g | $46.00 $87.00 | ||
Iron(III) citrate directly activates ferritin by providing ferric ions for binding and storage within the ferritin protein complex, enhancing its iron-sequestering capacity. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1060.00 $2923.00 $4392.00 $8333.00 | 19 | |
This iron chelator indirectly activates ferritin by binding free iron ions, promoting their sequestration by ferritin, and preventing iron-mediated oxidative stress. | ||||||