OTTMUSG00000016293 Activators
Serine protease inhibitor, Kunitz type 5 precursor (referred to as SPINT5), is an important protein in the regulation of protease activity in biological systems. SPINT5 belongs to the Kunitz type serine protease inhibitor family, known for their role in inhibiting various serine proteases. These proteases are involved in numerous physiological processes including digestion, immune response, blood coagulation, and cell migration. By regulating these proteases, SPINT5 helps maintain a balance in proteolytic activities, which is crucial for normal physiological functioning and preventing pathological conditions caused by unregulated protease activity. The inhibition of serine proteases by SPINT5 is not just important for controlling proteolytic activity, but also for modulating signaling pathways and cellular processes that are influenced by these enzymes.
The activation of SPINT5 is a sophisticated process influenced by various factors, primarily related to the cellular environment and the presence of cofactors. The structural integrity and functional efficacy of SPINT5 are highly dependent on its interaction with specific ions and molecules that stabilize its conformation. Elements like zinc, copper, magnesium, and calcium play a significant role in maintaining the structural stability of SPINT5, thus ensuring its effective binding and inhibition of target proteases. Additionally, the overall health of the cellular environment, supported by vitamins and antioxidants like ascorbic acid, Vitamin E, retinol, and nicotinamide, is crucial for the optimal function of SPINT5. These components help in preserving the structural integrity of SPINT5 and protecting it from oxidative stress, which could otherwise impair its function. The modulation of SPINT5 activity through these means highlights the intricate nature of its regulation and the importance of a balanced cellular environment for its proper functioning. Understanding the mechanisms and factors that activate SPINT5 is essential for comprehending its role in physiological processes and its potential implications in pathological conditions where protease activity is dysregulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor in various enzymatic reactions. Its presence can influence the structural stability and function of serine protease inhibitor, Kunitz type 5 precursor, leading to its activation by stabilizing its conformation for effective inhibition of target proteases. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper, like zinc, can act as a cofactor in numerous enzymes. Its involvement in enzymatic reactions can activate serine protease inhibitor, Kunitz type 5 precursor by altering its structural conformation, enhancing its ability to inhibit target proteases. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium ions are essential for many biological processes. Their presence can modulate enzymatic activities and structural configurations, potentially activating serine protease inhibitor, Kunitz type 5 precursor by facilitating its proper folding and functional conformation. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions play a significant role in stabilizing protein structures. Their binding can activate serine protease inhibitor, Kunitz type 5 precursor by promoting its structural integrity, essential for effective protease inhibition. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
Sodium ions influence protein stability and interaction with substrates. Their concentration can modulate the activity of serine protease inhibitor, Kunitz type 5 precursor, potentially activating it by stabilizing its interaction with target proteases. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
Potassium ions are crucial for maintaining cellular ionic balance. Their presence can affect protein conformation and function, possibly activating serine protease inhibitor, Kunitz type 5 precursor by optimizing its structural conformation for protease inhibition. | ||||||
Manganese(II) sulfate monohydrate | 10034-96-5 | sc-203130 sc-203130A | 100 g 500 g | $41.00 $107.00 | ||
Manganese acts as a cofactor in various biological processes. Its presence can activate serine protease inhibitor, Kunitz type 5 precursor by influencing its structural conformation and stability, enhancing its inhibitory function. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium is important for antioxidant defense mechanisms. Its role in enzymatic activities can lead to the activation of serine protease inhibitor, Kunitz type 5 precursor by influencing its structural stability and functional efficacy. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid, or Vitamin C, contributes to collagen synthesis and overall cellular health. It can activate serine protease inhibitor, Kunitz type 5 precursor by maintaining cellular conditions favorable for its stability and function. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $26.00 $52.00 $124.00 $326.00 | 3 | |
DL-α-Tocopherol (Vitamin E) is an antioxidant that protects cellular components from oxidative damage. Its presence can activate serine protease inhibitor, Kunitz type 5 precursor by preserving its structural integrity and functional capacity. | ||||||