OTOGL Inhibitors
Chemical inhibitors of OTOGL function by interfering with its phosphorylation state, which is essential for its role in the structural maintenance of hair cell stereocilia, crucial for hearing. Phorbol 12-myristate 13-acetate, commonly known as PMA, activates protein kinase C (PKC), a kinase that can phosphorylate OTOGL, leading to its inhibition. Staurosporine, a broad-spectrum kinase inhibitor, prevents various kinases including PKC from phosphorylating OTOGL, thereby inhibiting its function. Similarly, Bisindolylmaleimide I, Gö 6983, and Ro-31-8220 are potent inhibitors of PKC, which means they can prevent the phosphorylation of OTOGL. The specific inhibition of PKC results in reduced phosphorylation and subsequent functional inhibition of OTOGL. Calphostin C, which requires light to bind to PKC's regulatory domain, and Chelerythrine both serve to inhibit PKC's activity, thereby reducing the phosphorylation of OTOGL and inhibiting its function within the hair cells.
Continuing with PKC inhibitors, Sotrastaurin, Ruboxistaurin, and Enzastaurin selectively inhibit PKC, leading to a decrease in OTOGL phosphorylation. This lack of phosphorylation can inhibit OTOGL from maintaining proper hair cell structure and function. Balanol, as an ATP-competitive inhibitor, prevents PKC-and by extension, other kinases-from phosphorylating their target proteins, including OTOGL, which results in functional inhibition. Lastly, C1-10 is a cell-permeable compound that inhibits PKC, and consequentially, the phosphorylation of OTOGL is reduced. Through these various chemical interactions that lead to the decreased activity of PKC or its inhibition, the phosphorylation state of OTOGL is directly impacted, resulting in its functional inhibition and affecting its role in the auditory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which in turn can phosphorylate target proteins, leading to their inhibition. OTOGL, being a cytoplasmic peripheral membrane protein, could be regulated by PKC-mediated phosphorylation, which may inhibit its function in maintaining hair bundle integrity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that can inhibit various kinases including PKC. Through the inhibition of PKC, it can decrease the phosphorylation of OTOGL, thus inhibiting its function in the cohesion and stabilization of stereocilia in the inner ear. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. As PKC is capable of phosphorylating OTOGL, the inhibition of PKC activity by Bisindolylmaleimide I would lead to reduced phosphorylation and subsequent inhibition of OTOGL function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a pan-PKC inhibitor that could inhibit the phosphorylation of OTOGL by PKC, thereby reducing its ability to maintain the structure of hair cell stereocilia, which is essential for hearing. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
Ro-31-8220 is a PKC inhibitor that would prevent the phosphorylation of OTOGL, which may be necessary for its function in hair cells, leading to inhibition of its role in the ear. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $336.00 $1642.00 | 20 | |
Calphostin C inhibits PKC by binding to its regulatory domain in the presence of light. This inhibition could result in decreased phosphorylation of OTOGL, inhibiting its function in hair cell stereocilia. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a PKC inhibitor that could inhibit the phosphorylation of OTOGL, resulting in diminished function of OTOGL in hair cell stereocilia maintenance. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin is a selective PKC inhibitor that could dampen the phosphorylation of OTOGL, leading to its functional inhibition in the structural maintenance of the hair cells in the ear. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
Ruboxistaurin selectively inhibits PKCβ, which may phosphorylate OTOGL, and its inhibition could lead to reduced OTOGL function in hearing. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $254.00 $600.00 $1687.00 | 3 | |
Enzastaurin is a PKCβ inhibitor that could inhibit the phosphorylation of OTOGL, leading to its functional inhibition in the hair cells of the inner ear. | ||||||