ORP150 Inhibitors
ORP150 Inhibitors refers to a class of chemical compounds designed to interact with and modulate the activity of the endoplasmic reticulum-resident protein 150 (ORP150). ORP150, also known as oxygen-regulated protein 150 kDa, is an endoplasmic reticulum (ER)-localized chaperone that plays a pivotal role in cellular stress responses and protein folding. The inhibitors specifically target the function of ORP150, which is crucial for maintaining cellular homeostasis under conditions of stress, such as hypoxia.
These inhibitors typically exhibit a high degree of specificity for ORP150, disrupting its normal cellular functions. ORP150 is involved in the regulation of ER stress and unfolded protein response pathways, and its inhibition can impact these processes. The development of ORP150 inhibitors is grounded in the understanding that dysregulation of ER stress responses is implicated in various pathological conditions, including neurodegenerative diseases and certain cancers. Therefore, the modulation of ORP150 activity through inhibitors offers a potential avenue for exploring the underlying cellular mechanisms involved in stress responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid that can interfere with the protein folding process, which may affect HYOU1 function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Glycosylation inhibitor that can disrupt protein folding in the ER, possibly affecting HYOU1. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
HSP90 inhibitor that can disrupt the chaperone function, potentially influencing HYOU1 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can lead to increased stress on the ER, indirectly affecting HYOU1. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Selective inhibitor of eIF2α dephosphorylation, may affect HYOU1 related stress response. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Chemical chaperone that may modulate ER stress, thereby influencing HYOU1 activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Lysosomotropic agent that can alter glycosylation and ER stress, potentially affecting HYOU1. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Compound known to induce ER stress, which could influence HYOU1's role in the stress response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Polyphenol that may affect protein folding and ER stress, thereby possibly affecting HYOU1. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibitor of protein transport from the ER to the Golgi apparatus, may impact HYOU1 function. | ||||||