ORC4 Activators
ORC4 activators constitute a distinctive chemical class known for their ability to modulate the activity of ORC4, a crucial component of the Origin Recognition Complex involved in DNA replication initiation. The exploration of these activators entails a meticulous investigation into the methods governing the activation of ORC4, with a specific focus on unraveling the intricate signaling pathways and molecular interactions influencing its expression. Within this chemical class, researchers have identified specific compounds that can robustly enhance the transcriptional activity of ORC4, employing advanced methodologies to elucidate the nuanced mechanisms underlying its cellular regulation.
Cutting-edge techniques, including structure-activity relationship studies and computational modeling, have played a crucial role in refining our understanding of how ORC4 activators interact with cellular components to influence ORC4 expression. The design and synthesis of these activators have been guided by meticulous strategies to ensure the production of compounds with optimal pharmacokinetic and pharmacodynamic profiles. Additionally, the application of innovative approaches such as high-throughput screening and molecular dynamics simulations has enabled the identification of specific binding sites and conformational changes associated with the activation of ORC4. As research in the field of ORC4 activators progresses, these methodologies continue to contribute to a comprehensive exploration of the regulatory networks governing ORC4 expression, providing valuable insights into the broader cellular processes influenced by the modulation of this key player in DNA replication initiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ADP | 58-64-0 | sc-507362 | 5 g | $53.00 | ||
As a substrate for energy in cellular processes, ATP is essential for the activity of ORC4, which requires energy to assist in the unwinding of DNA and the initiation of replication. ATP binding leads to conformational changes in ORC4, enhancing its DNA-binding affinity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine has been shown to affect cell cycle progression. It modulates various signaling pathways, including those related to DNA replication. By altering the cellular energy status, caffeine could indirectly increase the demand for ORC4 activity during the DNA replication process. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Phosphatidylserine on the inner leaflet of the plasma membrane can signal to the nucleus and influence DNA replication initiation. By modulating membrane-associated signaling, it can indirectly enhance the localization and function of ORC4 at replication origins. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits general protein synthesis, which could lead to a compensatory increase in DNA replication initiation to balance cell cycle progression. This indirect effect may upregulate ORC4's role in the initiation of replication as the cell attempts to maintain homeostasis. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $48.00 $72.00 $265.00 $449.00 $1724.00 $112.00 | 16 | |
Thymidine is a nucleoside that can be incorporated into DNA. An increase in thymidine concentrations can lead to an upsurge in DNA synthesis activity, indirectly necessitating an increase in ORC4 function to accommodate the heightened demand for replication initiation. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $250.00 | 1 | |
Iodoacetamide alkylates cysteine residues, which can affect protein-protein interactions. It can potentially increase ORC4's affinity for other ORC subunits or DNA, thus enhancing the assembly and function of the ORC complex at replication origins. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, leading to cell cycle arrest at the G2/M phase. This may lead to an accumulation of factors necessary for the G1/S transition, indirectly enhancing ORC4 activity once the cell cycle resumes. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor, which leads to stalled replication forks and an increased need for replication re-initiation, potentially increasing ORC4's functional activity in the process of replication restart. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea is known to inhibit ribonucleotide reductase, causing a reduction in deoxyribonucleotide levels and stalling DNA replication. This stalling could lead to a compensatory increase in ORC4 activity to overcome the replication stress. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
Gemcitabine is a nucleoside analog that becomes incorporated into DNA, leading to replication stress. The resultant stress could indirectly enhance ORC4 activity as part of the cellular response to maintain replication under challenging conditions. | ||||||