OR8D2 Inhibitors
OR8D2 inhibitors are chemical compounds that specifically target the OR8D2 olfactory receptor, a member of the extensive G protein-coupled receptor (GPCR) family. OR8D2, like other olfactory receptors, is responsible for detecting specific odorant molecules in the environment, initiating a signal transduction pathway that ultimately leads to the perception of smell. OR8D2 inhibitors are designed to bind to this receptor and block its interaction with odorant ligands, thus preventing the activation of the receptor. The inhibition of OR8D2 can result in a disruption of the olfactory signaling associated with the receptor, providing a method to study its specific role in odor detection and signaling mechanisms.
Chemically, OR8D2 inhibitors encompass a range of molecules, from small organic compounds to peptides or other synthetic molecules, depending on the specific binding sites on the receptor. These inhibitors typically function by occupying the receptor's active site or by binding allosterically to alter the receptor's conformation, preventing it from interacting with its natural ligands. Identifying these compounds often involves high-throughput screening techniques, molecular docking studies, and structure-activity relationship (SAR) analyses to optimize the interactions between the inhibitor and the OR8D2 receptor. These inhibitors are valuable in the study of olfactory receptors, as they allow researchers to dissect the function of OR8D2 within the broader olfactory system. By blocking the receptor's activity, scientists can gain insights into the molecular basis of odor recognition, receptor-ligand specificity, and the broader dynamics of olfactory signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor could lead to hyperacetylation of histones, resulting in a less compact chromatin structure, which typically promotes gene expression. However, in some contexts, this can also lead to the recruitment of transcription repressors, potentially causing a downregulation of OR8D2 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine could demethylate the promoter region of the OR8D2 gene, which usually activates gene expression. However, if demethylation extends into regulatory regions binding repressors, this could inadvertently lead to decreased OR8D2 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This antibiotic intercalates into DNA and prevents the advancement of RNA polymerase along the DNA, which could lead to a halt in the transcription of the OR8D2 gene, thereby reducing its mRNA and protein levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
By specifically inhibiting RNA polymerase II, α-Amanitin could directly halt the transcription of OR8D2 mRNA, leading to a sharp decrease in OR8D2 protein synthesis. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
This glycosylation inhibitor could disrupt proper folding and stability of OR8D2 mRNA by inducing endoplasmic reticulum stress, which may result in reduced translation efficiency and decreased OR8D2 protein levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
As a proteasome inhibitor, Bortezomib could prevent the degradation of misfolded OR8D2 proteins, potentially leading to an unfolded protein response that downregulates OR8D2 gene expression as a protective cellular mechanism. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
This compound inhibits eukaryotic protein synthesis by interfering with ribosome function, which could directly decrease the synthesis of OR8D2 proteins. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
By inhibiting the splicing of pre-mRNA, Pladienolide B could disrupt the maturation of OR8D2 mRNA transcripts, leading to the production of non-functional mRNA that is rapidly degraded, thereby reducing OR8D2 protein levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
This inhibitor of the mammalian target of rapamycin (mTOR) could diminish protein synthesis, including the production of OR8D2, by reducing the activity of downstream effectors involved in translation initiation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This inhibitor of phosphatidylinositol 3-kinase (PI3K) could indirectly decrease the expression of OR8D2 by reducing the activity of downstream pathways essential for cell survival and protein synthesis, consequently leading to a reduction in OR8D2 levels. | ||||||