OR7G3 Activators
OR7G3 include a variety of compounds that influence the signaling pathways and cellular processes that lead to the protein's functional activation. Acetylcholine can bind to acetylcholine receptors associated with sensory neurons, which may lead to activation of OR7G3 in the context of olfactory signaling. Similarly, ions such as sodium, potassium, calcium, magnesium, and zinc play distinct roles in the neuronal activation cycle. Sodium ions contribute to the depolarization of sensory neurons, which may subsequently activate OR7G3. Potassium ions are responsible for the repolarization phase of action potentials, resetting the sensory neurons that express OR7G3. Calcium ions are pivotal in neurotransmitter release and could trigger a cascade of events that activate OR7G3. Magnesium ions help stabilize ATP, necessary for various signaling pathways, including those that may activate OR7G3. Zinc ions can modulate neuronal signaling and possibly influence pathways involving OR7G3.
cAMP and GTP are instrumental in the signal transduction mechanisms of olfactory receptors. The increase of cAMP, possibly through the action of forskolin, which activates adenylate cyclase, can lead to the activation of OR7G3. GTP binding and hydrolysis, critical steps in G-protein activation in olfactory neurons, can also result in the activation of OR7G3. Other chemical activators like icilin can activate transient receptor potential channels, leading to sensory neuron activation, which may include OR7G3. Menthol and capsaicin activate ionotropic receptors and vanilloid receptor subtype 1, respectively, causing the depolarization of sensory neurons. This neuronal excitation can extend to the olfactory signaling cascade involving OR7G3, culminating in its activation. These activators demonstrate the diverse molecular interactions that can lead to the functional activation of the olfactory receptor OR7G3, illustrating how various chemical signals can converge on a single protein to modulate its activity within sensory neurons.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Potassium | 7440-09-7 | sc-253297 | 1 g | $122.00 | ||
Potassium ions are involved in repolarization and the regulation of action potential in neurons; their regulated efflux is pivotal for the reset of sensory neurons that could express OR7G3. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions play a crucial role in neurotransmitter release at synapses; their intracellular increase might result in the activation of downstream signaling pathways involving OR7G3. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a second messenger important in many biological processes, including the signal transduction pathways of olfactory receptors like OR7G3, leading to its activation. | ||||||
Guanosine-5′-Triphosphate, Disodium salt | 86-01-1 | sc-507564 | 1 g | $714.00 | ||
GTP binding and hydrolysis are essential for G-protein activation in olfactory receptor neurons, which in turn can activate OR7G3 as part of the signal transduction mechanism. | ||||||
Icilin | 36945-98-9 | sc-201557 sc-201557A | 10 mg 50 mg | $91.00 $257.00 | 9 | |
Icilin is a synthetic super-agonist of the transient receptor potential channels, leading to sensory neuron activation, which might include activation of olfactory receptors like OR7G3. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can act as neuromodulators in the central nervous system and might influence the signaling pathways that include OR7G3, leading to its activation. | ||||||
(−)-Menthol | 2216-51-5 | sc-202705 sc-202705A | 1 g 50 g | $20.00 $41.00 | 2 | |
Menthol is known to activate certain ionotropic receptors leading to neuron excitation, which might extend to activation of the olfactory signaling cascade that includes OR7G3. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is an agonist of the vanilloid receptor subtype 1, which, when activated, can lead to depolarization of sensory neurons and potentially the activation of downstream olfactory receptors like OR7G3. | ||||||