OR6X1 Activators
OR6X1 vary widely in their structure and scent profiles, but all share the commonality of being able to initiate a cascade of biochemical events leading to the perception of smell. Isoamyl acetate, for instance, is recognized for its distinctive banana-like aroma and acts as a ligand to OR6X1, engaging with the olfactory receptor through its ligand-binding domain. This interaction induces a conformational modification of the receptor, which is a crucial step in the activation of the downstream signaling pathways intrinsic to the olfactory system. Similarly, benzaldehyde, with its almond scent, and ethyl vanillin, with a vanilla fragrance, bind to the active site of OR6X1, causing structural changes that precipitate a G-protein-coupled response within the olfactory neurons. This leads to the transmission of the sensory signal that is interpreted as smell.
Other chemicals such as methyl salicylate and cinnamaldehyde, known for their wintergreen and cinnamon odors respectively, also activate OR6X1 by binding directly to it. This ligand-receptor binding is the initial step in a series of intracellular reactions. Eugenol, limonene, and geraniol, the compounds behind the scents of cloves, citrus, and roses, engage OR6X1 in a similar manner, where their binding promotes a conformational change in the receptor, triggering the G-protein signaling cascade. This cascade includes the activation of second messengers within the cell that amplify the signal. Subsequent compounds such as citral, alpha-ionone, and anethole, which impart lemon, violet, and licorice scents, respectively, also serve as activating ligands to OR6X1. Their interaction with the receptor leads to the activation of the G-protein-coupled signaling pathway, which is essential for the propagation of the olfactory signal. Lastly, hexyl acetate contributes to this diverse array of scents with its fruity and floral notes, activating OR6X1 and thus participating in the complex process of smell perception through a similar biochemical signaling pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate is a compound known for its characteristic banana-like odor and is an ester that can activate olfactory receptors, such as OR6X1, by binding to the receptor's ligand-binding domain, leading to a conformational change and the subsequent activation of downstream signal transduction pathways involved in olfactory perception. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde is a synthetic compound with a vanilla-like scent that can serve as a ligand for OR6X1, binding to the receptor's active site, which activates the G-protein-coupled olfactory signaling pathway, resulting in sensory neuron excitation and signal transmission. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate, commonly known as wintergreen oil, can activate OR6X1 by binding directly to the receptor, initiating a conformational change that triggers the G-protein signaling pathway and resulting in the propagation of the olfactory signal. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde, which gives cinnamon its characteristic flavor and odor, can bind to olfactory receptors such as OR6X1, leading to the activation of the associated G-protein-coupled pathways and subsequent signal transduction for smell perception. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol, a key component of clove oil with a spicy aroma, can interact with OR6X1, and its binding can activate the receptor, prompting a signaling cascade through the associated G-protein pathway, resulting in the detection of the eugenol scent. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene, a citrus-scented terpene found in the rinds of citrus fruits, is capable of binding to and activating OR6X1, initiating a series of intracellular responses via G-protein-coupled signaling that leads to the perception of its citrus aroma. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, a sweet rose-like scented compound, can serve as an activating ligand for OR6X1, binding to the receptor and triggering a G-protein-coupled response, which results in the transmission of the floral scent signal. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, known for its strong lemon odor, can bind to and activate OR6X1, causing a change in receptor conformation that leads to the activation of associated G-protein signaling cascades involved in the olfactory system. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Alpha-ionone, with its violet-like scent, can act as an activating ligand to OR6X1 by binding to the receptor's active site, which induces the activation of the G-protein-coupled signaling pathway and the subsequent sensory response. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
Anethole, which has a sweet, licorice-like aroma, can activate OR6X1 through direct binding to the receptor, leading to G-protein activation and the initiation of a signaling cascade that results in the perception of its flavor and scent. | ||||||