OR6Q1 Activators
OR6Q1 include a variety of compounds that are known to interact with transient receptor potential (TRP) channels, which play a crucial role in the sensory transduction processes in olfactory neurons. Cinnamaldehyde and eugenol are capable of activating TRPA1 channels, leading to an influx of calcium ions into the sensory neurons. This increase in intracellular calcium is a key step in the signal transduction cascade that ultimately results in the activation of OR6Q1, facilitating the perception of odors. Similarly, menthol and camphor, although traditionally associated with cooling sensations, can also activate TRP channels such as TRPM8 and possibly TRPA1. This activation initiates a series of neuronal responses that can enhance the activity of OR6Q1 by modulating the neuronal excitability and calcium signaling within olfactory neurons.
Capsaicin, a compound found in chili peppers, is a specific agonist of TRPV1, which leads to neuronal activation that can indirectly result in the activation of OR6Q1 through the modulation of neuronal activity and calcium dynamics. Citronellal, geraniol, isoeugenol, and limonene also share this mechanism, functioning as activators of TRPA1 channels. These compounds can activate the olfactory receptors by initiating signal transduction events that lead to changes in the activity of the neurons expressing OR6Q1. Thymol and methyl salicylate further contribute to this array of chemical activators by their action on TRPA1 channels, altering the signaling pathways in olfactory neurons, which in turn leads to the activation of OR6Q1. Lastly, alpha-terpineol, which is also a TRPA1 activator, enhances the olfactory signal transduction by influencing the ion channel-mediated signaling pathways, thus facilitating the activation of OR6Q1 and the overall process of olfactory detection.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde is known to activate transient receptor potential cation channel subfamily A member 1 (TRPA1), which is expressed in sensory neurons and can lead to the activation of olfactory receptors like OR6Q1 by causing an influx of calcium ions that could modulate the olfactory signaling. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol activates TRPA1 channels, similar to cinnamaldehyde, which may lead to activation of olfactory receptors such as OR6Q1 by increasing intracellular calcium levels, thus enhancing olfactory signal transduction. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol acts on transient receptor potential cation channel subfamily M member 8 (TRPM8) and might also affect TRPA1, leading to cellular responses that activate olfactory receptors like OR6Q1 through modulation of intracellular ionic concentrations and neuronal excitability. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is a well-known agonist of TRPV1 and could activate sensory neurons, which may indirectly activate olfactory receptors like OR6Q1 through increased neuronal activity and calcium influx. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is an agonist of TRPA1 channels, which can lead to the activation of OR6Q1 by initiating signal transduction cascades in olfactory sensory neurons that result in olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol activates TRPA1 channels, potentially leading to the activation of olfactory receptor proteins such as OR6Q1 through modulation of sensory neuron signaling. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $62.00 $52.00 | ||
Isoeugenol has been shown to activate TRPA1 channels, which could lead to the activation of OR6Q1 by influencing sensory neuron signaling pathways that are involved in olfactory detection. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene may stimulate olfactory receptors indirectly by activating TRPA1 channels, leading to neuronal excitation and subsequent activation of OR6Q1 through calcium signaling pathways. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol activates TRPA1 channels, which may result in the activation of OR6Q1 by triggering signaling cascades in olfactory neurons that enhance the perception of smell. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate is known to activate TRPA1 channels, potentially leading to the activation of OR6Q1 by modifying the signaling in olfactory neurons and facilitating the olfactory response. | ||||||