OR5M11 Activators
OR5M11, such as isoamyl acetate, eugenol, anethole, citral, geraniol, benzaldehyde, methyl salicylate, vanillin, linalool, ethyl vanillin, hexanal, and alpha-ionone, play a crucial role in the perception of odors by binding to and activating this specific olfactory receptor. When these diverse aromatic compounds encounter the olfactory epithelium, they each can engage with OR5M11 by fitting into its ligand-binding domain. The binding of these chemicals to OR5M11 is the initial step in the activation of the receptor. This interaction induces a structural change in the receptor, which enables it to couple with intracellular G-proteins. The activation of G-proteins is a critical step, as it sets off a cascade of cellular events that ultimately lead to the depolarization of olfactory receptor neurons.
Upon depolarization, an electrical signal is generated and transmitted to the brain, where it is interpreted as a distinct smell. Isoamyl acetate, for instance, with its fruity banana-like aroma, and eugenol with its clove-like scent, each bind to OR5M11 to produce these recognizable odors. Similarly, anethole's anise aroma, citral's citrus scent, and geraniol's floral fragrance activate the OR5M11 receptor in analogous ways. Benzaldehyde's characteristic almond-like odor, methyl salicylate's wintergreen smell, and vanillin's creamy vanilla scent are all conveyed through the activation of OR5M11. Additionally, the floral and spicy notes of linalool, the more intense vanilla aroma of ethyl vanillin, the fresh scent of hexanal, and the violet-like fragrance of alpha-ionone, are also detected through the activation of this olfactory receptor. Each of these compounds is capable of inducing a unique conformational change in OR5M11 that is necessary to initiate the signaling process, illustrating the versatility and specificity of this receptor in odorant detection and the complexity of olfactory perception.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate is a chemical compound known to be an odorant for olfactory receptors, such as OR5M11. This molecule binds to the receptor's binding site, leading to a conformational change and subsequent activation of intracellular G-proteins, which in turn initiate a signaling cascade resulting in the perception of smell. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol is a phenylpropene, an allyl chain-substituted guaiacol, which can activate specific olfactory receptors including members of the OR5M family by binding to their odorant binding sites, thereby triggering an intracellular signal transduction pathway that results in olfactory receptor neuron depolarization and signal transduction. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
Anethole is an aromatic compound that is structurally similar to a subset of ligands known to bind and activate olfactory receptors. Upon binding to OR5M11, anethole is thought to cause a conformational change that leads to the activation of the receptor and its associated G-protein, initiating a signal transduction cascade that results in a sensory response. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a key component of lemongrass oil, is known to be a strong activator of certain olfactory receptors. It activates OR5M11 by binding to the specific ligand-binding domain of the receptor, which causes a conformational change and triggers G-protein signaling, leading to the transduction of olfactory signals. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, a monoterpenoid and an alcohol, is recognized by olfactory receptors due to its floral scent. Binding of geraniol to OR5M11 induces receptor activation, which in turn activates the associated G-proteins, leading to a cascade of intracellular events that culminate in a sensory signal. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate, a natural product of many plants, is a chemical that activates olfactory receptors by binding to the ligand-binding site of the receptor such as OR5M11, causing activation of the receptor and subsequent G-protein-mediated signal transduction processes. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin, the primary component of the extract of the vanilla bean, is an aromatic compound that can bind to and activate specific olfactory receptors like OR5M11, which triggers a conformational change in the receptor and activates the downstream G-protein signaling cascade. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool is a naturally occurring terpene alcohol found in many flowers and spice plants. It activates olfactory receptors such as OR5M11 by binding to the receptor's ligand-binding region, inducing a conformational change and leading to G-protein activation and a signaling cascade that results in olfactory perception. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde is a synthetic derivative of vanillin with a similar odor profile. It activates OR5M11 by binding to its ligand-binding site, initiating a receptor conformational change that triggers G-protein activation and subsequent signal transduction pathways involved in the sense of smell. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal is an aldehyde with a grassy odor, which activates olfactory receptors like OR5M11 by interacting with specific sites on the receptor, causing a conformational change that leads to the activation of G-proteins and the subsequent olfactory signal transduction pathway. | ||||||