Date published: 2025-12-19

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OR5H2 Inhibitors

Chemical inhibitors of Olfactory receptor 5H2 operate through diverse molecular mechanisms to impede the receptor's olfactory signal transduction capabilities. Alpha-ionone and Geraniol, for example, can inhibit Olfactory receptor 5H2 by competitively binding to the receptor's active site, thereby preventing interaction with natural odorant ligands. This competitive binding effectively blocks the activation of the receptor, inhibiting the initiation of olfactory signaling pathways. Similarly, Citral and 2-Phenylethanol target the ligand-binding domain of Olfactory receptor 5H2, also preventing the receptor from activating in response to its specific odorants. These chemicals exemplify direct inhibition strategies, where the presence of the inhibitor directly prevents the receptor from performing its biological function. On the other hand, chemicals like (-)-trans-Caryophyllene and 1,8-Cineole modulate Olfactory receptor 5H2 activity through allosteric modulation or interference with conformational changes necessary for signal transduction, respectively. These interactions result in the inhibition of the receptor's ability to detect and respond to olfactory stimuli. Menthol's method of inhibition involves modulating the receptor's ion channels, essential for initiating the electrical signal that results from receptor activation, offering a unique approach to inhibiting olfactory perception. Additionally, Methyl salicylate and Vanillin act by competing with natural odorants for binding sites on Olfactory receptor 5H2, thereby inhibiting the receptor's ability to respond to olfactory stimuli. Metal ions, such as Zinc ions and Copper(II) sulfate, provide examples of inhibiting the receptor through interactions that lead to structural or functional alterations, reducing the receptor's sensitivity to odorants. Through these varied mechanisms, each chemical listed contributes to the functional inhibition of Olfactory receptor 5H2, showcasing the complex interplay between chemical structure and receptor activity.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

α-Ionone

127-41-3sc-239157
100 g
$75.00
(0)

Alpha-ionone could inhibit Olfactory receptor 5H2 by competitively binding to the receptor's active site, thus preventing the receptor from interacting with its natural ligands and inhibiting the signal transduction pathway related to olfaction.

(−)-trans-Caryophyllene

87-44-5sc-251281
sc-251281A
sc-251281B
sc-251281C
1 ml
5 ml
25 ml
1 L
$79.00
$157.00
$437.00
$2861.00
1
(0)

(-)-trans-Caryophyllene might inhibit Olfactory receptor 5H2 through allosteric modulation, changing the receptor's conformation and thereby inhibiting its ability to bind to odorant molecules, leading to inhibition of olfactory signal transduction.

Citral

5392-40-5sc-252620
1 kg
$212.00
(1)

Citral could directly inhibit Olfactory receptor 5H2 by binding to the receptor's ligand-binding domain, which would prevent the receptor from activating in response to its specific odorants, thereby inhibiting the olfactory signaling pathway.

1,8-Cineole

470-82-6sc-485261
25 ml
$43.00
2
(0)

1,8-Cineole might inhibit Olfactory receptor 5H2 by interfering with the receptor's ability to undergo conformational changes necessary for signal transduction, leading to inhibition of the olfactory perception process.

Geraniol

106-24-1sc-235242
sc-235242A
25 g
100 g
$44.00
$117.00
(0)

Geraniol could inhibit Olfactory receptor 5H2 by competitively binding to the receptor, preventing activation by natural odorant ligands and thus inhibiting the olfactory signal transduction pathway.

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$82.00
$126.00
3
(1)

Limonene might inhibit Olfactory receptor 5H2 through competitive inhibition, by binding to the odorant-binding site and preventing the receptor from detecting its natural odorant molecules, thereby inhibiting olfactory signaling.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$38.00
$67.00
(0)

Menthol could inhibit Olfactory receptor 5H2 by modulating the receptor's ion channels, which are essential for initiating the electrical signal that results from receptor activation, thus directly inhibiting the receptor's function.

Methyl Salicylate

119-36-8sc-204802
sc-204802A
250 ml
500 ml
$46.00
$69.00
(1)

Methyl salicylate might inhibit Olfactory receptor 5H2 by binding to specific sites on the receptor, leading to a decrease in receptor activity and inhibiting the receptor's ability to transmit olfactory signals.

2-Phenylethanol

60-12-8sc-238198
250 ml
$68.00
(0)

2-Phenylethanol could inhibit Olfactory receptor 5H2 by competitively binding to the receptor's active site, preventing the receptor from interacting with its natural ligands and thereby inhibiting olfactory signal transmission.

Vanillin

121-33-5sc-251423
sc-251423A
100 g
500 g
$43.00
$122.00
1
(1)

Vanillin might inhibit Olfactory receptor 5H2 by competing with natural odorants for binding sites, thereby inhibiting the receptor's ability to respond to olfactory stimuli and transmit signals.