OR5B17 Activators
OR5B17 include a variety of compounds that are structurally diverse but share the ability to bind and activate this specific protein located in the olfactory sensory neurons. Acetylcholine, for instance, initiates the activation process by attaching to OR5B17-associated G-protein-coupled receptors (GPCRs), setting off a signaling cascade that leads to sensory neuron depolarization and the perception of odors. Similarly, anethole, citral, eugenol, isoamyl acetate, limonene, menthol, methyl salicylate, phenethyl alcohol, vanillin, benzaldehyde, and geraniol also activate OR5B17 by binding to these GPCRs. Each of these chemicals, upon binding to the receptor, induces a conformational change in the receptor structure, which triggers a series of intracellular events. These events include the activation of G-proteins that in turn activate various downstream effectors, such as adenylate cyclase, which ultimately leads to an increase in intracellular cAMP levels or the opening of ion channels.
The specific interaction of these chemicals with OR5B17 and their subsequent activation of olfactory GPCRs are crucial for the generation of neuronal signals that the brain interprets as distinct smells. For example, limonene's interaction leads to the perception of citrus odors, while menthol's activation of OR5B17 results in the sensation of minty scents. Similarly, vanillin interacts with the olfactory receptors to produce the characteristic vanilla odor, and benzaldehyde activates OR5B17 to give the sensation of almond-like odors. Each chemical's unique molecular structure interacts with the OR5B17 protein in a way that is specific enough to result in the perception of a wide array of aromas, from the sweetness of anethole to the floral notes of geraniol. These interactions and activations are instantaneous and precise, allowing for the differentiation and recognition of complex scents in our environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole interacts with GPCRs of the olfactory system, which includes OR5B17, leading to the activation of these receptors and subsequent signal transduction pathways that culminate in olfactory perception. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral binds and activates OR5B17 by engaging with its receptor site on olfactory GPCRs, triggering a conformational change that initiates signal transduction for olfactory processing. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates OR5B17 by binding to associated olfactory GPCRs, which initiates a G-protein signaling cascade essential for the translation of chemical signals into neuronal responses related to smell. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate activates OR5B17 by binding to its specific olfactory receptors, which are part of the GPCR family, initiating a sequence of intracellular events leading to sensory neuron activation. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene serves as an agonist for OR5B17 by interacting with olfactory GPCRs, resulting in the activation of the receptor and the downstream signaling necessary for the perception of citrus odors. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol activates OR5B17 through its action on GPCRs in the olfactory epithelium, inducing a signaling cascade that translates chemical signals into the sensation of minty scents. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates OR5B17 by engaging with the GPCR olfactory receptors, leading to the activation of these receptors, which is essential for the recognition and translation of wintergreen odors. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol activates OR5B17 by binding to specific GPCRs in the olfactory sensory neurons, which initiates a signaling pathway resulting in the detection of floral scents. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin activates OR5B17 by interacting with olfactory receptors that are part of the GPCR family, triggering intracellular signals that result in the perception of vanilla odor. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates OR5B17 by interacting with GPCRs in the olfactory system, which leads to a series of intracellular events culminating in the recognition and translation of floral and rose-like odors. | ||||||