OR52L1 Activators
OR52L1 include a range of substances that engage the protein through different mechanisms. Isobutylmethylxanthine, 3-Isobutyl-1-methylxanthine (IBMX), and Forskolin act by elevating intracellular cAMP levels, a crucial second messenger in cellular signaling. Isobutylmethylxanthine and IBMX inhibit phosphodiesterases, enzymes responsible for breaking down cAMP, thus preventing its degradation and leading to an accumulation inside the cell. This rise in cAMP activates protein kinase A (PKA), which can then phosphorylate various proteins, potentially including OR52L1, resulting in its activation. Forskolin, on the other hand, directly stimulates adenylyl cyclase, catalyzing the conversion of ATP to cAMP. This increase in cAMP similarly leads to the activation of PKA, which may subsequently phosphorylate and activate OR52L1.
OR52L1 can be activated by direct binding of specific odorant molecules. VUAA1, while originally identified as an agonist for insect olfactory receptors, engages OR52L1 through direct interaction, suggesting a ligand-receptor binding mechanism that triggers activation. Other chemicals like Anethole, Eugenol, Menthol, Citral, Geraniol, Benzaldehyde, Limonene, and Methyl salicylate are known odorants that activate OR52L1 by binding to its ligand-binding domain. This direct interaction induces a conformational change in the protein, which initiates a G-protein signaling cascade. The activation of OR52L1 by these odorant molecules leads to various downstream cellular responses, depending on the context of the receptor activation. Each of these chemicals has a distinct molecular structure that interacts with OR52L1, confirming the receptor's ability to recognize and respond to a diverse range of chemical signals.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
This methylxanthine is a known phosphodiesterase inhibitor that increases intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA), which in turn could phosphorylate target proteins, including G-protein coupled receptors (GPCRs) like OR52L1, leading to their activation. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole is a compound that is known to be an odorant for certain olfactory receptors. Through direct binding as an odorant ligand, it could activate OR52L1 by triggering a conformational change that initiates signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is another odorant molecule that binds to and activates certain olfactory receptors. By binding to OR52L1, eugenol could activate the receptor and its associated signaling pathways. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol is a ligand for various receptors, including some GPCRs related to sensory perception. It may activate OR52L1 by direct interaction and activation of the receptor’s ligand-binding domain. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, is an odorant known to activate specific olfactory receptors. It could activate OR52L1 by binding directly to the receptor and initiating a G-protein signaling cascade. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol is a terpene that acts as an odorant for certain olfactory receptors. It could activate OR52L1 through direct binding, causing a conformational change and subsequent signal transduction pathway activation. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene is a scent compound that can act as an odorant for olfactory receptors. It is capable of activating OR52L1 by directly binding to the receptor, leading to activation of its signal transduction mechanisms. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate is a compound with a wintergreen scent that activates certain olfactory receptors. By interacting with OR52L1, it could induce receptor activation and subsequent cellular responses. | ||||||