OR52K2 Activators
OR52K2 include a variety of compounds that are commonly found in natural and synthetic fragrances. These activators, such as isoamyl acetate, eugenol, methyl salicylate, benzaldehyde, 2-phenylethanol, ethyl vanillin, geraniol, citronellol, linalool, anethole, hexyl acetate, and citral, each have unique structures that enable them to interact specifically with the ligand-binding domain of OR52K2. Upon binding, these chemicals induce a conformational change in OR52K2, which is a critical first step in the activation of this olfactory receptor. Isoamyl acetate, with its distinctive banana-like odor, and eugenol, noted for its spicy clove aroma, both serve as ligands that can engage with OR52K2, leading to receptor activation and subsequent olfactory perception. Similarly, methyl salicylate, with its sweet, minty scent, and benzaldehyde, known for its almond-like fragrance, also bind to OR52K2 and activate the receptor.
These molecules, along with floral-scented 2-phenylethanol, vanilla-like ethyl vanillin, rose-scented geraniol, and citronellol with its lemony aroma, all participate in the precise molecular interaction with OR52K2. Linalool, which is characterized by a lavendar scent, anethole that offers a licorice aroma, fruity hexyl acetate, and citral, a key component in citrusy fragrances, also act as chemical activators of OR52K2. The binding of these diverse chemicals to OR52K2 triggers the receptor's activation and initiates the signal transduction pathways that are fundamental to the sense of smell. These interactions are not only specific but also essential for the proper functioning of the olfactory system, allowing for the discrimination and perception of a wide array of scents. The activation of OR52K2 by these odorant molecules is a testament to the intricate relationship between chemical structure and biological function, especially in the context of olfactory receptors and the sensing of environmental olfactory cues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isoamyl acetate is a compound known to be an odorant and could serve as a ligand for OR52K2, which is an olfactory receptor. By binding to OR52K2, isoamyl acetate causes a conformational change in the receptor, leading to its functional activation and subsequent signal transduction pathways involved in the perception of smell. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol is commonly found in essential oils and is used as a flavoring agent. It can activate OR52K2 by binding to the receptor's ligand-binding domain, inducing an activation signal that may propagate through the G-protein coupled receptor pathway, which OR52K2 is part of, leading to cellular responses associated with olfaction. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate is an organic ester naturally produced by many plant species. Its structure allows it to specifically interact with OR52K2, possibly by fitting into the receptor's binding pocket, causing activation and initiating the olfactory signal transduction cascade. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol is a fragrance compound with a floral scent, and it can activate OR52K2 by specifically interacting with the receptor's binding site, which induces activation and leads to the olfactory signaling pathway. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde is a synthetic compound with a vanilla-like scent. It can activate OR52K2 by mimicking the natural ligands of the receptor, binding to it, and causing activation that results in the transduction of olfactory signals. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol is a monoterpenoid and an alcohol. It can activate OR52K2 by binding to the receptor's active site, causing a conformational change that activates the receptor and initiates the olfactory signaling cascade. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol is a natural acyclic monoterpenoid. When it binds to OR52K2, it activates the receptor, initiating the signal transduction pathways associated with the sense of smell and the perception of floral and citrus odors. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool is a terpene alcohol found in many flowers and spice plants. It can activate OR52K2 by interacting with the receptor's specific binding sites, leading to activation and participation in the olfactory signaling processes. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $565.00 $310.00 | ||
Anethole is an aromatic compound that can activate OR52K2 by binding to the receptor, causing its activation, which then triggers the olfactory signal transduction mechanisms to convey the scent information. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate is an ester with a fruity odor. It activates OR52K2 by interacting with the receptor's ligand-binding domain, thus causing activation and leading to the olfactory signaling pathways associated with the perception of fruity scents. | ||||||