OR52I1 Activators
OR52I1 engage with the protein through various molecular interactions that trigger olfactory signal transduction. Diethyl phthalate, for instance, can disrupt endocrine function upon cellular entry, affecting olfactory signaling and leading to the activation of OR52I1. Similarly, isoamyl acetate, a flavor and fragrance agent, can activate the receptor by binding to its ligand-binding domain, prompting a conformational change that initiates the signaling process. Eugenol, found in essential oils, also activates OR52I1 by binding to the active site, inducing a cascade specific to olfactory receptors. Methyl salicylate mimics natural odorant molecules, thereby activating OR52I1, while benzaldehyde, an aromatic aldehyde, causes the olfactory signal transduction pathway to be initiated upon binding to the receptor.
Citral, anethole, and geraniol all interact with OR52I1's ligand-binding site. Citral, a component of lemongrass oil, causes a shape change in the protein, leading to activation. Anethole, found in anise and fennel, binds to the receptor and activates it by exploiting the receptor's sensitivity to its physical and electronic properties. Geraniol, from rose and palmarosa oils, similarly triggers activation through conformational changes. Limonene and alpha-pinene, which are major components of citrus and coniferous tree oils respectively, activate OR52I1 by specifically binding to the active site and hydrophobic pocket, causing the necessary conformational change for signaling. Beta-ionone, with its violet-like odor, and hexyl acetate, a fruity ester, also activate OR52I1 by binding to the ligand-binding domain, resulting in the conformational changes needed for olfactory signal transduction. Each of these chemicals, through their unique interactions with OR52I1, highlight the diverse mechanisms by which olfactory receptors can be activated by exogenous compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diethyl phthalate | 84-66-2 | sc-239738 sc-239738A | 25 ml 500 ml | $27.00 $33.00 | ||
Diethyl phthalate is a plasticizer that, upon entering cells, can disrupt endocrine function. Since OR52I1 is an olfactory receptor, it is sensitive to endocrine disruptors which can lead to activation of the receptor through altered olfactory signaling. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate is a flavor and fragrance agent known to activate olfactory receptors. It can activate OR52I1 by binding to the receptor's ligand-binding domain, triggering a conformational change and initiating signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is a compound found in essential oils such as clove oil. It can activate OR52I1 by binding to the receptor's active site and inducing a signaling cascade specific to olfactory receptors. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate is an ester naturally occurring in various plants. It activates OR52I1 by mimicking the natural odorant molecules that bind to the olfactory receptor, inducing a cellular response. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, can activate OR52I1 by interacting with the receptor's ligand-binding site, causing a shape change in the protein and leading to the activation of olfactory signal transduction pathways. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole, a component of anise and fennel, can activate OR52I1 by binding to the receptor, which is sensitive to the compound's shape and electronic properties, initiating an olfactory signaling response. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, found in rose oil and palmarosa oil, activates OR52I1 by binding to the receptor's ligand-binding site, causing a conformational change and subsequent activation of olfactory signaling pathways. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene, a major component in citrus oil, activates OR52I1 by binding specifically to the receptor's active site, causing a change in its conformation and initiating a signal transduction pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene, a monoterpene found in coniferous trees, activates OR52I1 by interacting with the receptor's hydrophobic pocket, leading to conformational changes and the activation of the olfactory signaling cascade. | ||||||
beta-Ionone | 14901-07-6 | sc-291976 | 25 ml | $83.00 | ||
Beta-Ionone, which has a violet-like odor, activates OR52I1 by binding to the ligand-binding domain of the receptor, causing conformational changes that lead to the activation of the olfactory signaling pathway. | ||||||