OR4N4 Activators
OR4N4 Activators are specialized chemical compounds that play pivotal roles in enhancing the functional activity of the olfactory receptor OR4N4. Compounds such as Forskolin and 3-Isobutyl-1-methylxanthine (IBMX) elevate intracellular levels of cAMP, a critical second messenger in olfactory transduction. The increased cAMP caused by these activators enhances the responsiveness of OR4N4 to odorant molecules, thus potentiating olfactory signal transmission. Direct agonists such as Biacetyl, Menthol, Eugenol, Anethole, Citral, and Cinnamaldehyde are naturally occurring or synthetic odorant molecules that interact with OR4N4, triggering the activation of the receptor directly. These compounds are essential for the olfactory perception by activating the OR4N4 receptor and initiating the signal cascade that ultimately results in the perception of odors.
Additional compounds, including Zinc Sulfate and Boric Acid, modulate OR4N4 activity by influencing the receptor's ability to bind odorant molecules, either by causing conformational changes or stabilizing the receptor-ligand complex. Adenosine and Sodium Saccharin may not be traditional odorants but can indirectly enhance OR4N4 activity through their effects on G protein-coupled receptor pathways or by mimicking the structure of odorant molecules, respectively. These OR4N4 activators, through their direct or indirect actions, ensure the precise functioning of the olfactory system by modulating the signal transduction processes that allow for the detection and discrimination of a wide array of odorants.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. The rise in cAMP may enhance the sensitivity of OR4N4 to odorant molecules by modulating the olfactory signal transduction pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases which increases intracellular cAMP levels by preventing its breakdown. Elevated cAMP enhances the activity of OR4N4 by promoting olfactory receptor signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions have been shown to modulate olfactory receptor function. Zinc may bind to OR4N4 and cause a conformational change that enhances its ability to bind to odorant molecules. | ||||||
Boric Acid | 10043-35-3 | sc-202083B sc-202083 sc-202083C sc-202083A sc-202083D | 50 g 500 g 1 kg 2.5 kg 5 kg | $37.00 $78.00 $122.00 $176.00 $316.00 | 10 | |
Boric acid can form complexes with sugars or diols, which might influence the interaction of odorants with OR4N4, potentially enhancing the receptor's activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with G protein-coupled receptors and could enhance OR4N4 activity indirectly by modulating G protein signaling pathways within olfactory sensory neurons. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Menthol is known to interact with sensory receptors and may act as an agonist to OR4N4, directly triggering the olfactory signaling pathway. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a compound found in cloves, can activate certain olfactory receptors. It may directly engage OR4N4, facilitating the initiation of olfactory signal transduction. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole, a flavoring agent, has a structure that could directly activate OR4N4 by acting as an odorant ligand, initiating olfactory receptor signaling. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a compound found in lemon and other citrus fruits, may directly interact with OR4N4 as an odorant, thereby enhancing the receptor's activity. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde, the compound responsible for cinnamon's flavor, could be a direct agonist for OR4N4, activating the receptor and its associated olfactory signaling pathways. | ||||||