OR4K13 Inhibitors
Inhibitors of OR4K13 function by engaging in competitive or allosteric interactions with the olfactory receptor, leading to a decrease in its ability to respond to odorant molecules. Many of these inhibitors are structurally similar to the natural ligands of OR4K13 and can therefore occupy the same binding site, effectively blocking the receptor's activation. For instance, certain flavor and fragrance compounds, which possess the capacity to bind the ligand-binding domain of OR4K13, act by obstructing the interaction between the receptor and its endogenous odorants, thus preventing the normal cascade of cellular signaling events that would lead to olfactory perception. Other inhibitors may act as inverse agonists, which means they not only block the receptor's activity but also reduce its basal activity level, further diminishing the receptor's signaling output.
Some inhibitors interact with the receptor in a manner that alters its conformation, potentially affecting the receptor's ability to undergo the conformational changes necessary for signal transduction. This can result in a reduction of the receptor's overall functional activity, as the receptor cannot effectively initiate a response upon activation by an odorant. Additionally, compounds that are not directly related to the olfactory system, such as those influencing taste perception, may also bind to OR4K13 and modify its structure or signaling capacity, leading to a generalized inhibition of its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acesulfame Potassium | 55589-62-3 | sc-210736 | 25 g | $245.00 | ||
This compound is known to interact with certain taste receptors but also thought to modulate olfactory receptors such as OR4K13 by competing with its natural ligands, leading to a decrease in the receptor's activation and subsequent signal transduction processes. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
As a flavor compound, cinnamaldehyde has the potential to bind to olfactory receptors, including OR4K13. Its binding could prevent the activation of the receptor by its specific ligands, resulting in decreased signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Found in cloves, eugenol may interact with OR4K13, serving as an inhibitor by occupying the ligand binding site and preventing activation by endogenous odorants, thus reducing the receptor's functional activity. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
This compound, with a banana-like odor, may act as an antagonist to OR4K13. By binding to the receptor's active site, it could inhibit the signaling cascade normally initiated by the receptor's natural ligands. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
A citrus scent compound that might compete with the natural ligands of OR4K13 for binding, potentially acting as an inhibitor and reducing the receptor's ability to initiate a cellular response upon activation. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
Could bind to OR4K13 and act as an inverse agonist, reducing the receptor's constitutive activity and thereby decreasing its overall signaling output. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
As an aldehyde with a fruity odor, octanal may serve as an inhibitor to OR4K13 by binding to the receptor's ligand-binding domain, thus blocking the receptor's activation and subsequent signaling. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
This aromatic alcohol, with a floral scent, is capable of binding to olfactory receptors and may inhibit OR4K13 by preventing its activation by natural ligands, thereby reducing signaling. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, the primary component of vanilla bean extract, could inhibit OR4K13 by interacting with the receptor's binding site, acting as an antagonist to the natural odorants and consequently decreasing receptor activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
This compound is known to have a modulatory effect on taste perception, and it could extend to olfactory receptors such as OR4K13 by binding and possibly altering the receptor structure or signaling, leading to reduced activity. | ||||||