Date published: 2025-12-24

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OR1C1 Inhibitors

Chemical inhibitors of Olfactory receptor 1C1 encompass a diverse range of compounds, each exhibiting a unique mechanism of inhibition. Limonene, Camphor, 1,8-Cineole, Methyl Salicylate, Cinnamyl Alcohol, Isopentyl acetate, Cinnamic Aldehyde, Anethole, Geraniol, Citral, cis-3,7-Dimethyl-2,6-octadien-1-ol, and Farnesol are notable examples. These chemicals primarily function by competitively binding to the receptor's active site, a mechanism that directly impedes the receptor's ability to interact with natural odorants. For instance, Limonene and 1,8-Cineole achieve inhibition by occupying the ligand-binding sites of Olfactory receptor 1C1, thereby blocking the binding of natural odorants and inhibiting the receptor's function in olfactory perception. Similarly, Methyl Salicylate and Cinnamyl Alcohol bind to the active site of the receptor, hindering its interaction with natural odorant molecules and thus inhibiting its sensory function. The inhibition of Olfactory receptor 1C1 by these chemicals is further exemplified by Isopentyl acetate and Cinnamic Aldehyde, which mimic natural odorants, competitively binding to the receptor's active site and preventing the binding of actual odorants. This competitive inhibition is a critical aspect of their action, as it effectively nullifies the receptor's ability to detect and respond to natural odorants. Anethole, Geraniol, Citral, and cis-3,7-Dimethyl-2,6-octadien-1-ol also follow this pattern, binding to the receptor's odorant-binding site and blocking the interaction with natural odorants, thus inhibiting olfactory signaling. Farnesol's action is similar, offering competitive inhibition at the receptor's active site, which impedes the binding of natural odorant molecules and impairs the receptor's ability to function in olfactory perception. Each of these chemicals, through their unique interactions with Olfactory receptor 1C1, demonstrates the varied ways in which this receptor can be inhibited, showcasing the intricate mechanisms of olfactory receptor modulation.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$82.00
$126.00
3
(1)

Limonene inhibits Olfactory receptor 1C1 by competitively binding to its odorant-binding site, thereby preventing the binding of natural odorants and inhibiting the receptor's olfactory signal transduction.

1,8-Cineole

470-82-6sc-485261
25 ml
$43.00
2
(0)

1,8-Cineole inhibits Olfactory receptor 1C1 through a competitive inhibition mechanism by occupying its ligand-binding sites, which prevents the binding of natural odorants and inhibits the receptor's function in olfactory perception.

Methyl Salicylate

119-36-8sc-204802
sc-204802A
250 ml
500 ml
$46.00
$69.00
(1)

Methyl Salicylate inhibits Olfactory receptor 1C1 by binding to the receptor's active site. This binding hinders the receptor's ability to interact with natural odorant molecules, thereby inhibiting its sensory function.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$105.00
$221.00
(0)

Isopentyl acetate inhibits Olfactory receptor 1C1 by mimicking natural odorants and binding to the receptor's active site, preventing the binding of actual odorants and thereby inhibiting olfactory signaling.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

Cinnamic Aldehyde inhibits Olfactory receptor 1C1 by binding to its ligand-binding site, inducing a conformational change that prevents normal olfactory signaling.

trans-Anethole

4180-23-8sc-253727
1 ml
$27.00
1
(0)

Anethole inhibits Olfactory receptor 1C1 by competitively binding to its active site, thereby preventing the binding of natural odorants and inhibiting the receptor's function in olfactory perception.

Geraniol

106-24-1sc-235242
sc-235242A
25 g
100 g
$44.00
$117.00
(0)

Geraniol inhibits Olfactory receptor 1C1 by binding to its odorant-binding site, thus blocking the binding of natural odorant molecules and inhibiting the receptor's sensory function.

Citral

5392-40-5sc-252620
1 kg
$212.00
(1)

Citral inhibits Olfactory receptor 1C1 by competing with natural odorants for the receptor's active site, which leads to a decrease in the receptor's ability to detect these natural odorants and inhibits its olfactory role.

cis-3,7-Dimethyl-2,6-octadien-1-ol

106-25-2sc-234382
5 ml
$51.00
(0)

cis-3,7-Dimethyl-2,6-octadien-1-ol inhibits Olfactory receptor 1C1 by binding to the receptor's ligand-binding site, preventing the interaction with natural odorants and thus inhibiting the receptor's function in olfactory signaling.

Farnesol

4602-84-0sc-204748
sc-204748A
50 ml
100 ml
$275.00
$367.00
2
(1)

Farnesol inhibits Olfactory receptor 1C1 through competitive inhibition at the receptor's active site, which hinders the binding of natural odorant molecules and impairs the receptor's ability to function in olfactory perception.