OR13J1 Activators
OR13H1 activators exert their effects through various biochemical mechanisms, each tailored to modulate the intricate signaling pathways olfactory receptors rely on. One such mechanism involves the modulation of intracellular cyclic nucleotide levels, a critical determinant of OR13H1 activity. Certain activators engage directly with enzymes that catalyze the production of cyclic AMP, thereby increasing its concentration within the olfactory sensory neurons. This elevation in cAMP facilitates the activation of kinase-mediated phosphorylation pathways, culminating in the heightened sensitivity and responsiveness of OR13H1 to olfactory stimuli. Other activators prevent the breakdown of cAMP, maintaining its cellular concentration and ensuring sustained activation of the receptor. The intracellular milieu is further optimized by activators that increase the availability of essential cofactors for kinases, enhancing the phosphorylation and thus the activation of OR13H1.
Beyond the cyclic nucleotide cascade, additional activators influence the cellular context in which OR13H1 operates, further fine-tuning its functional activity. Key ions act as allosteric modulators or serve as indispensable cofactors for enzymes that phosphorylate key proteins, including OR13H1. These ions may induce conformational changes in the receptor or enable crucial post-translational modifications that enhance receptor function. For instance, certain ions are known to play a pivotal role in olfactory signal transduction by affecting the activity of various enzymes and channels involved in the pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-specific inhibitor of phosphodiesterases, IBMX prevents cAMP degradation, which in turn can sustain the activation of cAMP-dependent pathways enhancing the signal transduction related to OR13H1 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions have been shown to modulate olfactory receptor function by acting as allosteric modulators. Zinc can bind to specific sites on olfactory receptors, including OR13H1, potentially enhancing odorant binding affinity or receptor activation. | ||||||
trans-Anethole | 4180-23-8 | sc-253727 | 1 ml | $28.00 | 1 | |
A flavor compound that, due to its structural similarity to eugenol, a known olfactory receptor activator, could interact with OR13H1, potentially causing a conformational change in the receptor that leads to increased activity. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
A phenylpropene, eugenol is a known activator of olfactory receptors and could directly interact with the ligand-binding domain of OR13H1, leading to receptor activation and subsequent signal transduction. | ||||||
Diethyl phthalate | 84-66-2 | sc-239738 sc-239738A | 25 ml 500 ml | $27.00 $33.00 | ||
Used in fragrances, this compound could theoretically interact with OR13H1 as a ligand, leading to receptor activation and enhancing the olfactory signal transduction pathway. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
As an ester of salicylic acid, methyl salicylate might interact with OR13H1 and other olfactory receptors, activating them and inducing olfactory signal transduction. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
A key component in lemon scent, citral may bind and activate OR13H1, facilitating olfactory receptor activation and signaling. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
A fragrance compound found in several flowers, could activate OR13H1 by binding directly to the receptor, causing a conformational change and initiating the olfactory signaling cascade. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
This synthetic compound is a known activator of olfactory receptors. It could interact with OR13H1, leading to increased receptor activity and signal transduction related to olfactory perception. | ||||||