Date published: 2025-10-25

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OR13H1 Inhibitors

OR13H1 inhibitors are chemical compounds that have the ability to decrease the functional activity of the OR13H1 olfactory receptor. These inhibitors exert their effects by binding to various sites on the receptor, which can lead to changes in conformation and prevent the receptor from interacting with its natural ligands. Some of these inhibitors act by direct competition, occupying the odorant-binding site on OR13H1, thereby preventing the activation of the receptor that would normally occur upon binding of specific odorant molecules. For example, certain ketones, esters, and aldehydes are known to have molecular structures that enable them to fit within the OR13H1 binding pocket, where they act as antagonists to block the receptor's function. Other inhibitors act allosterically, binding to sites distinct from the odorant-binding site and inducing conformational changes that render the receptor inactive or less sensitive to its activating ligands. The effect of these inhibitors on OR13H1 is also influenced by the presence of metal ions, which can alter the receptor's structure and function. Some metal ions can interact with amino acid residues in the OR13H1's binding pocket, leading to allosteric inhibition and reducing the receptor's ability to be activated by its natural odorants. Additionally, specific aromatic compounds are known to bind competitively to the OR13H1 receptor, preventing the binding of natural odorant molecules, which would otherwise induce a signaling cascade leading to olfactory perception.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Zinc

7440-66-6sc-213177
100 g
$47.00
(0)

Zinc ions bind to the olfactory receptor OR13H1, causing a conformational change that reduces its ability to bind its specific odorant molecules, therefore decreasing the receptor's functional activity.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$45.00
$120.00
$185.00
3
(1)

Copper ions interact with histidine residues in the binding pocket of OR13H1, leading to allosteric inhibition of the olfactory receptor and preventing activation by its ligands.

2-Heptanone

110-43-0sc-238060
1 ml
$94.00
(0)

2-Heptanone acts as an antagonist to OR13H1 by binding to the receptors odorant-binding site, thereby inhibiting the activation of the receptor by its natural ligands.

1-Octen-3-ol

3391-86-4sc-237604
25 g
$49.00
(0)

This compound binds competitively to OR13H1, inhibiting its activation by preventing the binding of the endogenous odorant molecules to the receptor.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

Binds to OR13H1, altering the receptor's conformation and impairing its ability to respond to its specific activating ligands.

D-Limonene

5989-27-5sc-205283
sc-205283A
100 ml
500 ml
$82.00
$126.00
3
(1)

As an antagonist, binds to OR13H1 and inhibits its activation by occupying the ligand-binding site and preventing interaction with natural odorant molecules.

1,8-Cineole

470-82-6sc-485261
25 ml
$43.00
2
(0)

Interacts with OR13H1 at its ligand-binding site, functioning as a competitive inhibitor and decreasing the receptor's functional activity.

Isopentyl acetate

123-92-2sc-250190
sc-250190A
100 ml
500 ml
$105.00
$221.00
(0)

This compound acts as a competitive antagonist to OR13H1 by binding to the receptor's odorant site, inhibiting the natural activation process.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$38.00
$67.00
(0)

Binds to specific sites on OR13H1, causing a change in receptor conformation that inhibits its activation by natural odorant ligands.

trans-Anethole

4180-23-8sc-253727
1 ml
$27.00
1
(0)

Inhibits OR13H1 by competitively binding to its odorant binding site, thereby preventing the activation of the receptor by its endogenous odorant molecules.