OR13H1 Activators
The functional activation of OR13C8, a member of the olfactory receptor family, can be influenced by a variety of chemical compounds that affect intracellular signaling pathways or bind directly to the receptor. Activation can occur through the enhancement of cAMP levels within the cell, a critical second messenger in olfactory transduction. This elevation of cAMP occurs either through stimulation of adenylate cyclase or inhibition of phosphodiesterases, resulting in a potentiation of the receptor's signal transduction capabilities. Some compounds achieve this indirectly, while others may modulate receptor function by stabilizing its structure or directly interacting with the binding site, which is crucial for receptor sensitivity and proper response to odorants. Direct agonists of OR13C8 engage in ligand-receptor interactions, initiating the cascade of intracellular events that lead to the perception of smell.
Furthermore, the activation of OR13C8 is influenced by various organic compounds that are structurally similar to the natural ligands of olfactory receptors. These molecules, often found in natural flavors and fragrances, have the capacity to bind to the receptor, triggering a series of cellular responses that amplify the receptor's activity. The direct binding of these ligands to OR13C8 is a key mechanism in its functional activation, as it leads to the conformational changes necessary for signal propagation within olfactory neurons.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Directly stimulates adenylate cyclase, increasing cAMP levels which could enhance the sensitivity and activity of OR13C8 by modulating the intracellular signaling that governs the olfactory transduction pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, increasing cAMP by preventing its breakdown, thereby potentially enhancing OR13C8 function through similar cAMP-dependent mechanisms as forskolin. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Acts as a modulator of olfactory receptor function, and could enhance OR13C8 sensitivity and signal transduction by stabilizing receptor conformation or interacting directly with the receptor binding site. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Known to interact with specific olfactory receptors, it may act as an agonist to OR13C8, directly increasing its activity through ligand-receptor binding. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
A flavor compound that can activate certain olfactory receptors, potentially including OR13C8, through direct binding and activation of olfactory signal transduction pathways. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
A floral scent compound that could act as an agonist for OR13C8, activating the receptor through direct ligand interaction and subsequent signaling events. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Known as a fruit and banana-flavor compound, it could serve as an agonist for OR13C8, leading to increased receptor activity upon binding. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
A terpenoid alcohol that may bind and activate OR13C8, enhancing its activity by acting as a ligand for the receptor. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
A component found in lemongrass oil, it might interact with and activate OR13C8 through specific ligand-receptor interactions, initiating downstream olfactory signaling. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
A compound found in anise that could potentially activate OR13C8 by acting as a direct ligand, leading to increased olfactory receptor activity. | ||||||