OR13A1 Activators
OR13A1 Activators are a diverse group of chemical compounds that enhance the functional activity of this specific olfactory receptor by acting on various aspects of its signaling pathway or cellular environment. Retinal, by serving as a ligand, binds directly to OR13A1, triggering a conformational change crucial for signal transduction, while adenine can stabilize the receptor in its active state, thus promoting olfactory signaling. Cyclodextrin, through its ability to form inclusion complexes, increases the solubility and availability of odorants, facilitating their interaction with OR13A1. Metal ions like zinc sulfate, copper(II) sulfate, and magnesium sulfate modulate the activity of OR13A1 and downstream elements such as G-proteins; the former two may alter the receptor's responsiveness to ligands, while magnesium is vital for the activation of G-proteins. Sodium bicarbonate influences the receptor's microenvironmental pH, potentially enhancing ligand affinity and activation, and cholesterol optimizes membrane fluidity, which is essential for effective ligand-receptor dynamics.
Further contributing to the enhancement of OR13A1's signaling are compounds that influence the receptor's activity through indirect mechanisms. GTPγS, a non-hydrolyzable GTP analog, provides sustained activation of the G-proteins associated with OR13A1, increasing the intensity of the olfactory signal. Forskolin elevates intracellular cAMP, a secondary messenger that amplifies the signaling cascade triggered by OR13A1 activation. Phosphatidylethanolamine plays a role in maintaining the structural integrity of the olfactory receptor membrane, which is likely to support the stability and proper function of OR13A1. Lastly, oleic acid, by integrating into the cell membrane, may create a more conducive lipid environment for OR13A1, thus facilitating enhanced receptor-ligand interactions and signal transduction. Collectively, these activators work in concert to boost the sensitivity and responsiveness of OR13A1 in olfactory perception.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $129.00 $379.00 | 7 | |
Retinal binds to OR13A1 as a ligand, which is a critical step in the activation of this olfactory receptor, leading to a conformational change and subsequent signal transduction processes that amplify the receptor's sensory signal. | ||||||
Adenine, cell culture grade | 73-24-5 | sc-291834 sc-291834A sc-291834B | 5 g 25 g 100 g | $84.00 $210.00 $557.00 | 2 | |
Adenine interacts with olfactory receptors like OR13A1 by stabilizing the receptor in its active conformation, enhancing the probability of olfactory signal transduction. | ||||||
β-Cyclodextrin | 7585-39-9 | sc-204430 sc-204430A | 25 g 500 g | $60.00 $538.00 | 3 | |
Cyclodextrin forms inclusion complexes with odorant molecules, increasing their solubility and availability to bind to OR13A1, thereby potentiating the receptor's activation and signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can modulate olfactory receptor function by stabilizing receptor structure. For OR13A1, zinc may enhance ligand binding affinity or signal transduction efficiency, leading to increased olfactory signaling. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Similar to zinc, copper ions can influence olfactory receptors. Copper(II) sulfate may act on OR13A1 by altering its conformational state, thereby increasing its responsiveness to odorant molecules. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium is essential for G-protein activation, which is downstream of OR13A1 activation. Magnesium sulfate can therefore enhance the G-protein signaling cascade that OR13A1 is part of, leading to amplified sensory signal transduction. | ||||||
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $21.00 $29.00 $43.00 $84.00 $697.00 | 1 | |
Sodium bicarbonate can modulate the pH microenvironment of olfactory receptors. For OR13A1, a change in pH might increase odorant receptor affinity or receptor activation, enhancing olfactory signal transduction. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is a component of cell membranes and can affect membrane fluidity and receptor mobility. For OR13A1, cholesterol can enhance ligand-receptor interactions by optimizing the receptor's membrane environment for signal transduction. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can potentiate the signaling cascade of G-protein-coupled receptors like OR13A1, thereby enhancing the receptor's ability to transmit olfactory information. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid can integrate into cell membranes, potentially altering the lipid environment and improving receptor-ligand interactions for membrane proteins like OR13A1, thereby enhancing its activation and functional activity in olfactory signaling. | ||||||