OR10H2 Activators
OR10H2 include a diverse set of compounds such as isoamyl acetate, eugenol, benzyl acetate, methyl salicylate, geranyl acetate, citronellol, anisaldehyde, benzaldehyde, heptanal, octanal, nonanal, and decanal. These chemicals interact with OR10H2 via binding to specific sites on the protein, leading to its activation. The binding of a chemical like isoamyl acetate or benzyl acetate to OR10H2 initiates a conformational shift within the protein structure. This change is crucial as it triggers the associated G-protein to exchange GDP for GTP, activating it. Activated G-proteins then go on to influence adenylate cyclase, which increases the conversion of ATP to cyclic AMP (cAMP) within olfactory sensory neurons. The rise in cAMP levels ultimately opens ion channels that result in the depolarization of the neuron, creating an electrical signal that is transmitted to the brain, where it is interpreted as a distinct smell.
OR10H2 for various scent molecules allows for a broad spectrum of odors to be detected and differentiated. For example, eugenol and anisaldehyde, despite having distinct scents, both activate OR10H2 by inducing similar molecular events. Geranyl acetate and citronellol, with their floral and citrus-like odors, respectively, also bind to OR10H2, illustrating the versatility of this receptor in recognizing a range of aromatic structures. The aldehydes, from benzaldehyde to decanal, each with a unique carbon chain length, demonstrate that OR10H2 can accommodate molecules of differing sizes, indicating that the receptor's binding pocket has a certain flexibility. This ability to bind multiple ligands with varying structures and to transduce this binding into a neuronal response underlies the complexity and sophistication of the olfactory system, with OR10H2 playing a pivotal role in translating chemical stimuli into the perception of smell.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
This compound is a known odorant for OR10H2, a member of the olfactory receptor family. When bound to OR10H2, isoamyl acetate causes a conformational change that activates the receptor, initiating a signal transduction cascade that results in the perception of smell. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol is recognized by OR10H2 as an aromatic compound. Its interaction with OR10H2 activates the receptor, leading to a G-protein-mediated signal transduction pathway, culminating in the olfactory response. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate can bind to OR10H2, triggering the receptor's activation. This activation leads to a cascade of intracellular events, including the production of cAMP, which is a secondary messenger in olfactory signal transduction. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate is detected by OR10H2, and binding to this receptor activates it, ultimately leading to the neuronal response for smell. This process involves the activation of adenylate cyclase, and the subsequent increase in cAMP levels within olfactory sensory neurons. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate is an ester that can serve as a ligand for OR10H2, leading to receptor activation. Upon binding, the receptor undergoes a conformational change that activates the associated G-protein, initiating olfactory signal transduction mechanisms. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol interacts with OR10H2, causing activation of the receptor. This interaction promotes the G-protein signaling pathway, which is crucial for the translation of chemical signals into electrical signals in the olfactory system. | ||||||
4-Methoxybenzaldehyde | 123-11-5 | sc-238884 sc-238884A sc-238884B sc-238884C | 5 g 100 g 250 g 1 kg | $30.00 $42.00 $72.00 $124.00 | ||
Anisaldehyde is a known activator of OR10H2, which induces a change in the receptor that leads to the activation of G-proteins and the subsequent olfactory signal transduction pathway, resulting in the perception of its distinct anise-like odor. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal is an aldehyde that can activate OR10H2 by binding to the receptor, which in turn activates the associated G-proteins involved in the olfactory signaling cascade. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal interacts with OR10H2, serving as an agonist that activates the receptor. This activation triggers the G-protein-coupled signaling events leading to the perception of odors. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $67.00 | ||
Nonanal is capable of activating OR10H2 by directly binding to the receptor, facilitating the activation of the olfactory signal transduction pathway, which involves the G-protein-coupled receptor system and the production of cAMP. | ||||||