OR10H1 Activators
OR10H1 engage with the receptor in a lock-and-key mechanism, where each chemical compound binds to a specific site on the protein, initiating a series of conformational changes. Isoamyl acetate, benzyl acetate, methyl salicylate, eugenol, ethyl vanillin, citronellol, geraniol, α-ionone, β-ionone, hexyl salicylate, β-damascone, and lilial are examples of such activators. Each of these compounds possesses a unique structure that allows them to fit into the binding site of OR10H1, much like a key fits into a lock. Upon binding, these molecules trigger an alteration in the shape of OR10H1, which is the first step in a cascade of reactions leading to signal transduction. This binding is specific and causes the OR10H1 to undergo a change that is communicated to the inside of the olfactory sensory neuron.
The activation of OR10H1 by these chemicals results in the recruitment and activation of G-proteins that are coupled to the receptor. These G-proteins serve as molecular switches that, once activated, set off a series of downstream cellular events. The interaction of compounds like citronellol and geraniol with OR10H1 leads to the activation of these G-proteins, which then dissociate from the receptor and go on to influence other molecules within the cell, ultimately generating a nerve impulse that is perceived as scent. Similarly, α-ionone and β-ionone, with their distinct floral and violet-like aromas, engage with OR10H1 to produce a similar effect. The binding of hexyl salicylate, β-damascone, and lilial to OR10H1 further exemplifies the diversity of molecular interactions possible with this olfactory receptor, each leading to the transmission of olfactory information to the brain, resulting in the perception of a wide range of scents.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
This chemical is a known odorant that can directly activate OR10H1 by binding to its ligand-specific site, inducing conformational changes that trigger the G-protein-coupled receptor pathway leading to signal transduction within olfactory sensory neurons. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate is an aromatic ester that can directly activate OR10H1 by interacting with specific sites on the protein, initiating a cascade of cellular responses characteristic of the olfactory signaling pathway. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, a common plant extract also known as wintergreen oil, activates OR10H1 by binding to its receptor site, which in turn activates the associated G-proteins, leading to a cellular response in the olfactory system. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a compound found in clove oil, has the capacity to activate OR10H1 through direct interaction with the receptor, causing changes in the receptor's structure and activating the downstream olfactory signal transduction processes. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde is an analog of vanillin with a strong scent, and it activates OR10H1 by binding to its active site, which promotes the activation of the olfactory receptor's associated G-proteins and subsequent signal transduction. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol, a monoterpenoid found in rose and geranium oils, activates OR10H1 by direct binding to the receptor, which leads to the activation of G-protein signaling pathways in olfactory sensory neurons. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a component of rose oil and palmarosa oil, activates OR10H1 by binding to the receptor, facilitating the activation of the G-protein coupled receptor pathway that is integral to the olfactory response. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Alpha-ionone, with its violet-like aroma, activates OR10H1 by molecular interaction with the receptor, which triggers the G-protein-coupled signal cascade involved in the perception of smell. | ||||||
beta-Ionone | 14901-07-6 | sc-291976 | 25 ml | $83.00 | ||
Beta-ionone, which is structurally similar to alpha-ionone and found in flower fragrances, activates OR10H1 by engaging with the receptor site, resulting in the activation of the olfactory signal transduction pathway. | ||||||