Olfr986 Activators
Olfr986 is an olfactory receptor, part of the G-protein-coupled receptor (GPCR) superfamily, which plays a critical role in olfaction. Olfactory receptors like Olfr986 are responsible for the detection of odorant molecules, translating these chemical stimuli into neuronal signals. The functional activation of Olfr986, and receptors like it, involves the specific binding of odorants to the receptor, which induces conformational changes critical for signaling. Upon binding of an odorant molecule, Olfr986 undergoes a conformational change that enables its interaction with G-proteins. This interaction is crucial for the receptor's activation as it leads to the activation of adenylate cyclase, an enzyme responsible for converting ATP into cyclic AMP (cAMP). The rise in cAMP levels is pivotal, as it activates protein kinase A (PKA), which then phosphorylates various cellular targets, leading to diverse cellular responses. This cascade of intracellular events represents the primary mechanism through which odorant perception is translated into a meaningful neuronal response.
The specificity of ligand-receptor interactions in the olfactory system, as exemplified by Olfr986, underlies the complex and nuanced nature of scent detection and discrimination. Each odorant molecule, through its unique structural characteristics, interacts with specific olfactory receptors, triggering a distinct pattern of receptor activation and neuronal signaling. This intricate system allows for the perception of a vast array of odors, contributing to the richness of the olfactory experience. Understanding the mechanisms of receptor activation, such as that of Olfr986, provides valuable insights into the molecular basis of smell and the broader field of sensory perception. Moreover, this knowledge enhances our understanding of GPCR signaling pathways, which are critical in numerous physiological processes and are key targets in drug discovery and interventions. The study of receptors like Olfr986, their activation by specific chemicals, and the resulting signaling pathways, continues to be a significant area of research in sensory biology and pharmacology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate activates Olfr986 by binding to its orthosteric site, inducing a conformational change that facilitates G-protein coupling. This leads to adenylate cyclase stimulation, increasing cyclic AMP levels, triggering PKA activation, and functionally activating Olfr986. | ||||||
Pentyl acetate | 628-63-7 | sc-215691 | 250 ml | $65.00 | ||
Pentyl acetate activates Olfr986 through direct interaction with its ligand-binding domain, triggering a structural shift. This enables G-protein coupling and subsequent adenylate cyclase activation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr986. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $50.00 | ||
Ethyl hexanoate activates Olfr986 by binding to specific sites on the receptor, causing a conformational rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr986. | ||||||
Methyl benzoate | 93-58-3 | sc-215338 sc-215338A | 25 g 500 g | $23.00 $32.00 | ||
Methyl benzoate activates Olfr986 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels, and activating PKA, thereby functionally activating Olfr986. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr986 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr986. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $31.00 $102.00 $408.00 | ||
Benzyl alcohol activates Olfr986 by binding directly to the receptor, inducing a conformational change. This activation stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, an increase in cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr986. | ||||||
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $120.00 $320.00 | ||
Ethyl acetate activates Olfr986 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr986. | ||||||
Propyl acetate | 109-60-4 | sc-250792 | 500 ml | $20.00 | ||
Propyl acetate activates Olfr986 by binding to the receptor's active site, causing a conformational shift. This shift facilitates G-protein coupling and activation, leading to adenylate cyclase stimulation, an increase in cyclic AMP, and activation of PKA, functionally activating Olfr986. | ||||||
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $70.00 $93.00 | ||
3-Methyl-1-butanol activates Olfr986 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr986. | ||||||
Methyl propionate | 554-12-1 | sc-215367 sc-215367A | 100 ml 500 ml | $51.00 $140.00 | ||
Methyl propionate activates Olfr986 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr986. | ||||||