Olfr985 Activators
Olfr985, like other olfactory receptors in the G-protein-coupled receptor (GPCR) family, plays a significant role in the detection and discrimination of a vast array of odorant molecules. The functional activation of Olfr985, as seen with many olfactory receptors, is contingent on the specific binding of odorant molecules to the receptor. This interaction triggers a series of structural and conformational changes in Olfr985, which are the initial steps in the receptor's activation process. The specificity of this ligand-receptor interaction underlines the complexity and precision of the olfactory system in detecting and differentiating between different scents.
Upon ligand binding, Olfr985 undergoes a conformational change, facilitating its coupling with G-proteins. This coupling is a crucial step in the receptor's activation as it leads to the activation of adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP is a critical event as it activates protein kinase A (PKA), which subsequently phosphorylates various cellular targets. This cascade of events results in a range of cellular responses, including changes in ion channel activity and gene expression. The precise mechanisms of activation and the specific downstream effects vary depending on the receptor and the ligand involved. The study of receptors like Olfr985, and their activation mechanisms, not only provides insight into the molecular basis of smell but also enhances our understanding of GPCR signaling pathways, which are pivotal in numerous physiological processes and potential targets for interventions. Understanding how specific chemicals, such as those listed in the table, activate Olfr985 enriches our comprehension of sensory perception, molecular recognition, and cellular signaling in the context of olfaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate activates Olfr985 by binding to its orthosteric site, inducing a conformational change that facilitates G-protein coupling. This activation leads to adenylate cyclase stimulation, increasing cyclic AMP levels, triggering PKA activation, and functionally activating Olfr985. | ||||||
Isoeugenol | 97-54-1 | sc-250186 sc-250186A | 5 g 100 g | $63.00 $53.00 | ||
Isoeugenol activates Olfr985 through direct interaction with its ligand-binding domain, triggering a structural shift. This enables G-protein coupling and subsequent adenylate cyclase activation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr985. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr985 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr985. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr985 by binding directly to the receptor, inducing a conformational change. This activation stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, an increase in cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr985. | ||||||
(+)-Carvone | 2244-16-8 | sc-239480 sc-239480A | 5 ml 25 ml | $33.00 $84.00 | 2 | |
Carvone activates Olfr985 by binding to the receptor's active site, causing a conformational shift. This shift facilitates G-protein coupling and activation, leading to adenylate cyclase stimulation, an increase in cyclic AMP, and activation of PKA, functionally activating Olfr985. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl acetate activates Olfr985 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr985. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol activates Olfr985 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr985. | ||||||
4-Methoxybenzaldehyde | 123-11-5 | sc-238884 sc-238884A sc-238884B sc-238884C | 5 g 100 g 250 g 1 kg | $30.00 $42.00 $72.00 $124.00 | ||
4-Methoxybenzaldehyde activates Olfr985 by interacting with specific binding sites on the receptor, leading to a conformational shift. This shift facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr985. | ||||||