Olfr980 Activators
Olfr980, a member of the olfactory receptor family, plays a critical role in the sense of smell. These receptors, classified as G protein-coupled receptors (GPCRs), are predominantly expressed in the olfactory epithelium. The primary function of Olfr980, as with other olfactory receptors, is to detect specific odorant molecules in the environment. This detection is vital for the perception of a wide array of scents, essential for various aspects of life including locating food, sensing danger, and social communication. The activation of Olfr980 by an odorant molecule is the first step in a complex process that leads to the generation of a neural signal, ultimately perceived as a distinct smell by the brain.
The mechanism of activation of Olfr980 is characterized by several key steps, beginning with the binding of an odorant molecule to the receptor. This interaction induces a conformational change in Olfr980, crucial for activating the receptor. Following this activation, Olfr980 interacts with a G protein located on the inner surface of the cell membrane. This interaction leads to the exchange of GDP for GTP on the G protein's alpha subunit, activating the G protein. The activated G protein then stimulates adenylate cyclase, an enzyme that converts ATP to cyclic AMP (cAMP). The increase in cAMP activates protein kinase A (PKA), which phosphorylates various proteins, including ion channels. The phosphorylation of these channels results in their opening, leading to changes in the cell's membrane potential. This change generates a neural signal that is transmitted to the brain and interpreted as a specific scent. The specificity of this process, from ligand binding to neural signal generation, highlights the complexity and precision of the olfactory signaling pathway. This pathway is essential for an organism's ability to detect and differentiate a vast array of odorant molecules, playing a significant role in survival and various behavioral responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Propanol | 67-63-0 | sc-391000C sc-391000 sc-391000B sc-391000A | 1 ml 25 ml 100 ml 500 ml | $32.00 $52.00 $62.00 $87.00 | 1 | |
2-Propanol binds to Olfr980, resulting in the activation of the receptor and initiation of its specific signaling pathway, leading to downstream cellular responses. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
D-Limonene interacts with Olfr980, activating the receptor through a conformational change which then propagates the signal through its specific signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
α-Pinene binds to and activates Olfr980, which leads to a series of reactions in the signaling pathway associated with this receptor, resulting in a cellular response. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $43.00 | 2 | |
1,8-Cineole activates Olfr980 by binding to its ligand-binding domain, causing a change in the receptor's structure and initiating its signaling pathway. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol activates Olfr980 through binding to the receptor, causing a conformational shift that initiates the signaling pathway of the receptor. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol binds to Olfr980, activating the receptor and leading to the initiation of its associated signaling mechanisms. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol activates Olfr980 by interacting with its ligand-binding domain, inducing a structural change that triggers the activation of the receptor's signaling pathway. | ||||||