Olfr937 Activators
Olfr937 is an olfactory receptor that belongs to the large family of G protein-coupled receptors (GPCRs), which are critical for the detection of a wide range of odorants. The activation of Olfr937 is essential for the perception of specific smells. This receptor, like other olfactory receptors, is activated through the binding of specific chemical compounds, known as odorants. The binding of an activator to Olfr937 triggers a conformational change in the receptor, which then initiates a cascade of intracellular signaling events. This cascade typically involves the activation of a G protein, leading to the stimulation of adenylyl cyclase. The enzyme adenylyl cyclase is responsible for converting ATP to cyclic AMP (cAMP), and the increase in cAMP levels is a crucial step in the signaling pathway. Elevated cAMP activates protein kinase A (PKA), which phosphorylates various target proteins, ultimately leading to changes in cellular function and the generation of a nerve impulse.
The specificity of the activation of Olfr937 by different chemicals is determined by the molecular interactions between the odorant and the receptor. Each chemical activator has a unique structure that allows it to specifically bind to and activate Olfr937. This specificity is critical for the accurate perception of smells, enabling the olfactory system to distinguish between different odorants. The array of activators for Olfr937, ranging from floral to citrus scents, reflects the receptor's role in detecting a broad spectrum of smells. Understanding the activation mechanisms of olfactory receptors like Olfr937 is fundamental to comprehending how smells are detected and discriminated. It sheds light on the intricate signaling pathways involved in olfactory perception and contributes to our understanding of how the olfactory system influences various physiological and behavioral responses. The study of Olfr937 and other olfactory receptors remains a vital area of research in neurobiology and sensory science, providing insights into the complex nature of smell perception.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr937 by binding to the receptor, triggering a G protein-coupled receptor (GPCR) signaling pathway. This interaction leads to the activation of adenylyl cyclase, resulting in an increase in cyclic AMP (cAMP) levels. The elevated cAMP activates protein kinase A (PKA), crucial for the functional activation of Olfr937, facilitating signal transduction in olfactory sensory neurons. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde, known for its cinnamon aroma, activates Olfr937 by direct interaction with the receptor. This binding initiates GPCR signaling, stimulating adenylyl cyclase and leading to a rise in cAMP levels. Increased cAMP levels are key for the functional activation of Olfr937, enhancing its role in the perception of cinnamon-related odors. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
1,8-Cineole, a compound with a eucalyptus scent, activates Olfr937 through receptor interaction, triggering GPCR signaling. The activation of adenylyl cyclase and the subsequent increase in cAMP levels are crucial for the functional activation of Olfr937, contributing to its role in olfactory signal transduction. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal, with its lemon-like aroma, activates Olfr937 by binding to the receptor, initiating GPCR-mediated signaling. The resultant activation of adenylyl cyclase increases cAMP production. This increase in cAMP is critical for the functional activation of Olfr937, enhancing its role in olfactory perception. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, known for its rose-like scent, activates Olfr937 by interacting with the receptor, triggering GPCR signaling. This activation stimulates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP is crucial for the functional activation of Olfr937, contributing to its role in the detection of floral odors. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene, a major component in citrus oil, activates Olfr937 through its interaction with the receptor, inducing GPCR signaling. This leads to the activation of adenylyl cyclase, increasing intracellular cAMP levels. The increase in cAMP is essential for the functional activation of Olfr937, aiding in olfactory signal transduction. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, with its floral aroma, activates Olfr937 by binding to the receptor, initiating a GPCR-mediated signaling pathway. The activation of adenylyl cyclase and the subsequent rise in cAMP levels are key for the functional activation of Olfr937, playing a significant role in olfactory perception. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene, a component of pine oil, activates Olfr937 by interacting with the receptor, triggering GPCR signaling. The stimulation of adenylyl cyclase and the increase in cAMP production are vital for the functional activation of Olfr937, facilitating its role in the detection of pine-related odors. | ||||||
beta-Ionone | 14901-07-6 | sc-291976 | 25 ml | $83.00 | ||
Beta-Ionone, possessing a violet-like scent, activates Olfr937 through receptor interaction, inducing GPCR signaling. This leads to increased adenylyl cyclase activity and a rise in cAMP levels. Elevated cAMP levels are critical for the functional activation of Olfr937, playing a significant role in floral odor perception. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, a compound with a sweet rose odor, activates Olfr937 by directly interacting with the receptor, inducing GPCR signaling. This activation leads to increased adenylyl cyclase activity and a subsequent rise in cAMP levels. Increased cAMP levels are essential for the functional activation of Olfr937, playing a pivotal role in the olfactory signaling process. | ||||||