Olfr923 Inhibitors
Olfr923, a member of the olfactory receptor gene family, plays a vital role in the perception of odors in Mus musculus (house mouse). It functions as a G-protein-coupled receptor (GPCR), participating in the recognition and transduction of odorant signals. The olfactory receptor gene family, to which Olfr923 belongs, is characterized by its single coding-exon genes and the 7-transmembrane domain structure shared with neurotransmitter and hormone receptors. Olfr923's specific nomenclature in this organism is distinct from other species.
Inhibition of Olfr923 can be achieved through various chemicals that target key pathways involved in olfactory signal transduction. These chemicals disrupt processes such as GPCR signaling, cAMP-dependent signaling, calcium signaling, and downstream effectors. Amiloride, for instance, hinders ion flow in olfactory receptor cells, impairing Olfr923's response to odorants. Forskolin, on the other hand, elevates cAMP levels, indirectly reducing Olfr923 function. Pertussis Toxin interferes with G-protein signaling, while Thapsigargin disrupts calcium homeostasis, both indirectly suppressing Olfr923. These inhibitors collectively contribute to the modulation of olfactory perception by targeting various aspects of the olfactory signal transduction pathway. The intricate regulation of Olfr923 and related pathways highlights the complexity of odorant perception in mice and provides opportunities for further research into olfactory receptor function and inhibition.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride inhibits Olfr923 by modulating ion channels involved in olfactory signal transduction. It disrupts ion flow and reduces the receptor's ability to respond to odorant molecules, leading to a decrease in olfactory perception. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, indirectly inhibiting Olfr923 by increasing cAMP levels in olfactory receptor cells. Elevated cAMP reduces Olfr923 function, impairing its response to odorants and diminishing olfactory perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin targets the endoplasmic reticulum calcium pump, indirectly impacting Olfr923 via the calcium signaling pathway. Disruption of calcium homeostasis reduces Olfr923's ability to transmit odorant signals, resulting in decreased olfactory perception. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis Toxin inhibits Olfr923 by interfering with G-protein signaling pathways. It ADP-ribosylates specific G-proteins, indirectly suppressing Olfr923 function, and reducing the perception of odorant molecules in the olfactory system. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein inhibits Olfr923 by targeting the phospholipase C signaling pathway. It disrupts downstream signaling events, indirectly suppressing Olfr923 function, and subsequently reducing the perception of odorant molecules. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol indirectly inhibits Olfr923 by modulating intracellular signaling pathways. It affects downstream events that impact Olfr923 function, leading to a reduced response to odorant stimuli and diminished olfactory perception. | ||||||
U-73343 | 142878-12-4 | sc-201422 sc-201422A | 5 mg 25 mg | $91.00 $343.00 | 17 | |
U73343 inhibits Olfr923 by targeting the phospholipase C signaling pathway. It disrupts downstream signaling events, indirectly suppressing Olfr923 function, and subsequently reducing the perception of odorant molecules. | ||||||