Olfr914 Activators
Olfr914, an olfactory receptor protein, is integral to the detection and differentiation of specific odorant molecules. As a member of the G-protein coupled receptors (GPCRs) family, Olfr914 plays a critical role in converting chemical signals from the environment into neural signals in the olfactory system. The functional activation of such receptors is a key step in the perception of smells. This process begins when specific odorant molecules bind to the olfactory receptors, like Olfr914, located in the nasal epithelium. The binding of these molecules to Olfr914 induces a conformational change in the receptor, which is the primary mechanism for initiating signal transduction. The activation mechanism of Olfr914, similar to other olfactory receptors, is highly specific and dependent on the structural compatibility between the odorant and the receptor. This specificity allows the olfactory system to detect a wide range of odors with precision. Upon binding of an odorant molecule, such as isovaleric acid or hexanal, Olfr914 undergoes a conformational change, which triggers the activation of associated G-proteins. This activation sets off a cascade of intracellular events, such as the production of secondary messengers including cyclic AMP (cAMP) and the elevation of intracellular calcium levels. These secondary messengers amplify the olfactory signal and lead to the opening of ion channels, ultimately resulting in a neural response. This specificity of activation is crucial for the accurate perception of odors, allowing the olfactory system to discern a vast array of scents.
Furthermore, the range of chemicals that can activate Olfr914 highlights the broad specificity of olfactory receptors, enabling the detection of various odorant molecules with distinct scents. The activation of Olfr914 by diverse chemicals, each with unique structural features, exemplifies the complex nature of olfactory perception. The precise interaction between these chemicals and Olfr914 is essential for the functional activation of the receptor, leading to the accurate transduction of olfactory signals. This intricate interplay between olfactory receptors and odorant molecules is fundamental to our sense of smell, playing a critical role in our interaction with the environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $29.00 | ||
Isovaleric acid activates Olfr914 by binding to its olfactory receptor sites. This interaction induces a conformational change in Olfr914, triggering the activation of G-protein coupled signaling pathways. The activation of these pathways results in increased intracellular calcium levels and cyclic AMP, crucial for the functional activation and signal transduction of Olfr914, contributing to the perception of its distinct odor. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, a common aldehyde with a grassy odor, activates Olfr914 by binding to its specific olfactory receptor sites. This binding causes a structural alteration in Olfr914, which initiates the activation of G-protein coupled intracellular signaling pathways. These pathways, particularly those involving the elevation of cyclic AMP, are essential for the functional activation of Olfr914, facilitating the transmission of olfactory signals. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr914 through its interaction with the receptor's olfactory binding sites. This interaction results in a conformational change in Olfr914, leading to the activation of downstream G-protein coupled pathways. The activation of these pathways, especially those increasing cyclic AMP levels, plays a vital role in the functional activation and signal transduction of the olfactory receptor Olfr914. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $67.00 | ||
Nonanal, a compound with a citrus-like scent, activates Olfr914 by binding to its olfactory receptor sites. This binding induces a change in the receptor's conformation, triggering the activation of associated G-protein coupled signaling pathways. These pathways, including the rise in intracellular calcium and cyclic AMP levels, are crucial for the functional activation and proper signal transduction of Olfr914. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal activates Olfr914 by binding to its olfactory receptor sites, leading to a conformational change in the receptor. This change facilitates the activation of G-protein coupled pathways, resulting in a series of intracellular signaling events. These events, particularly the increase in cyclic AMP, are essential for the functional activation of Olfr914, playing a key role in the perception of decanal's odor. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal, a natural compound with a lemon scent, activates Olfr914 by binding to its olfactory receptor sites. This interaction induces a structural alteration in Olfr914, leading to the activation of G-protein coupled intracellular signaling pathways. The activation of these pathways, especially those that result in the increase of intracellular calcium levels, is crucial for the functional activation of Olfr914. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr914 by interacting with its specific olfactory receptor binding sites. This binding causes a change in the receptor's structure, triggering the activation of G-protein coupled signal transduction pathways. The activation of these pathways, especially those involving cAMP, is essential for the functional activation of Olfr914, contributing to the perception of citronellol's floral scent. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr914 through binding to its olfactory receptor sites. This interaction induces a conformational change in the receptor, triggering the activation of G-protein coupled pathways. The subsequent intracellular signaling cascade, involving the rise of cyclic AMP, leads to the functional activation of Olfr914, essential for the olfactory perception associated with linalool's floral aroma. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene, a terpene with a pine-like aroma, activates Olfr914 by binding to its olfactory receptor sites, causing a structural alteration. This interaction leads to the activation of G-protein coupled intracellular signaling pathways. The activation of these pathways, particularly the increase of cyclic AMP levels, plays a crucial role in the functional activation of the olfactory receptor Olfr914. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate activates Olfr914 through molecular binding at its specific olfactory receptor sites. This chemical's structural compatibility with Olfr914 enables it to bind effectively, altering the receptor's conformation. This binding triggers the activation of downstream G-protein coupled pathways, essential for the transduction of olfactory signals mediated by Olfr914. | ||||||