Olfr894 Activators
Olfr894 is an olfactory receptor protein responsible for detecting and transducing specific odorant signals, allowing us to perceive and differentiate various scents in our environment. Activation of Olfr894 involves a complex interplay of chemicals and signaling pathways that collectively contribute to its functional role in odor detection. The primary function of Olfr894 is to recognize and respond to specific odorants. When an odorant molecule binds to Olfr894, it undergoes a conformational change that activates the receptor. This activation can occur through direct binding of chemicals like Isoamyl Acetate and Pentanol to Olfr894's receptor site, or indirectly through the modulation of intracellular pathways like the cAMP-dependent PKA pathway by chemicals like 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) and 3-Methyl-2-oxovaleric acid.
Indirect activators, such as Thymol and Geraniol, influence Olfr894 by up-regulating its expression through specific signaling pathways. These chemicals enhance the synthesis of Olfr894 protein, resulting in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. In summary, Olfr894 plays a crucial role in our sense of smell, and its activation is orchestrated by a diverse range of chemicals that either directly or indirectly enhance its responsiveness to odorants, allowing us to perceive and distinguish various scents in our environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl Acetate directly activates Olfr894 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr894 in olfactory signal transduction. | ||||||
Methyl benzoate | 93-58-3 | sc-215338 sc-215338A | 25 g 500 g | $23.00 $33.00 | ||
Methyl Benzoate directly activates Olfr894 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr894 in olfactory signal transduction. | ||||||
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone directly activates Olfr894 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr894 in olfactory signal transduction. | ||||||
Thymol | 89-83-8 | sc-215984 sc-215984A | 100 g 500 g | $97.00 $193.00 | 3 | |
Thymol directly activates Olfr894 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr894 in olfactory signal transduction. | ||||||
3-Methyl-2-oxovaleric Acid | 1460-34-0 | sc-484817 | 1 g | $326.00 | ||
3-Methyl-2-oxovaleric acid indirectly activates Olfr894 by influencing the olfactory signal transduction pathway. It enhances the production of cAMP, leading to increased PKA activity, which in turn promotes the functional activation of Olfr894 by amplifying the receptor's response to odorant molecules. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) indirectly activates Olfr894 by mimicking cAMP. It enhances cAMP-dependent protein kinase (PKA) phosphorylation of olfactory receptors, amplifying their sensitivity to odorants and promoting the functional activation of Olfr894 in odor detection. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin directly activates Olfr894 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr894 in olfactory signal transduction. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol directly activates Olfr894 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr894 in olfactory signal transduction. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol directly activates Olfr894 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr894 in olfactory signal transduction. | ||||||