Olfr893 Activators
Olfr893 is an olfactory receptor protein responsible for detecting and transducing odorant signals, allowing us to perceive and differentiate various scents in our environment. Activation of Olfr893 involves a complex interplay of chemicals and signaling pathways that collectively contribute to its functional role in odor detection. The primary function of Olfr893 is to recognize and respond to specific odorants. When an odorant molecule binds to Olfr893, it undergoes a conformational change that activates the receptor. This activation can occur through direct binding of chemicals like Pentanol and Allyl Methyl Disulfide to Olfr893's receptor site, or indirectly through the modulation of intracellular pathways like the cAMP-dependent PKA pathway by chemicals like 8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) and 3-Methyl-2-oxovaleric acid.
Indirect activators, such as Retinoic Acid and Thapsigargin, influence Olfr893 by up-regulating its expression through specific signaling pathways. These chemicals enhance the synthesis of Olfr893 protein, resulting in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. In summary, Olfr893 plays a crucial role in our sense of smell, and its activation is orchestrated by a diverse range of chemicals that either directly or indirectly enhance its responsiveness to odorants, allowing us to perceive and distinguish various scents in our environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is an indirect activator of Olfr893. It influences the retinoic acid receptor signaling pathway, which up-regulates Olfr893 expression by binding to retinoic acid response elements in its promoter region. This results in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) indirectly activates Olfr893 by mimicking cAMP. It enhances cAMP-dependent protein kinase (PKA) phosphorylation of olfactory receptors, amplifying their sensitivity to odorants and promoting the functional activation of Olfr893 in odor detection. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin directly activates Olfr893 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr893 in olfactory signal transduction. | ||||||
3-Methyl-2-oxovaleric Acid | 1460-34-0 | sc-484817 | 1 g | $326.00 | ||
3-Methyl-2-oxovaleric acid indirectly activates Olfr893 by influencing the olfactory signal transduction pathway. It enhances the production of cAMP, leading to increased PKA activity, which in turn promotes the functional activation of Olfr893 by amplifying the receptor's response to odorant molecules. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose influences Olfr893 activation through the glycolytic pathway. It modulates glucose metabolism, indirectly enhancing olfactory receptor expression, leading to an amplification of the receptor's response to odorant molecules and functional activation. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl Acetate directly activates Olfr893 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr893 in olfactory signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates Olfr893 by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. This leads to elevated intracellular calcium levels, which enhance olfactory receptor sensitivity and promote the functional activation of Olfr893 in response to odorants. | ||||||