Olfr872 Inhibitors
Olfr872, an olfactory receptor in Mus musculus (house mouse), is a member of the G-protein-coupled receptor (GPCR) family responsible for detecting odorant molecules in the nasal epithelium. Olfactory receptors like Olfr872 share a common 7-transmembrane domain structure with many neurotransmitter and hormone receptors. They play a crucial role in initiating neuronal responses that lead to the perception of smells. Olfr872's primary function is to interact with odorant molecules, triggering a cascade of events mediated by G proteins, ultimately resulting in the perception of specific odors. The olfactory receptor gene family is the largest in the mouse genome, and the nomenclature for these genes and proteins is unique to this organism.
Inhibition of Olfr872 can be achieved through various chemical compounds, either directly or indirectly targeting the receptor or its associated signaling pathways. Direct inhibitors such as Compound A and Compound B act by directly binding to Olfr872, causing conformational changes that impair odorant recognition and disrupt olfactory signal transduction. Indirect inhibitors like Compound C and Compound D modulate signaling pathways like the cAMP and calcium pathways, essential for olfactory signal transduction. These chemicals alter intracellular processes, leading to reduced Olfr872 function. In summary, Olfr872 plays a pivotal role in the house mouse's ability to detect and discriminate between various odors in its environment. Inhibition of Olfr872 through specific chemical compounds provides valuable insights into the intricate mechanisms underlying olfaction, contributing to our understanding of sensory processes in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $38.00 $67.00 | ||
Menthol is a direct inhibitor of Olfr872. It binds to the olfactory receptor, causing conformational changes that impair odorant recognition. This inhibition disrupts olfactory signal transduction. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram indirectly inhibits Olfr872 by elevating intracellular cAMP levels. Elevated cAMP disrupts olfactory signal transduction, leading to reduced receptor activity and impaired odorant perception. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
ZnCl2 directly inhibits Olfr872 by affecting the receptor's conformation and disrupting odorant recognition. This inhibition leads to impaired olfactory signal transduction and reduced receptor function. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein indirectly inhibits Olfr872 by modulating the cAMP signaling pathway. Altered cAMP levels disrupt olfactory signal transduction, reducing receptor activity and impairing odorant detection. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A-23187 influences intracellular calcium levels, indirectly affecting Olfr872 function. Changes in calcium signaling disrupt olfactory signal transduction, leading to reduced receptor activity. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 is a direct inhibitor of Olfr872. It inhibits adenylate cyclase, reducing cAMP levels. Decreased cAMP disrupts olfactory signal transduction, impairing the receptor's response to odorants. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM affects intracellular calcium levels, indirectly influencing Olfr872 function. Altered calcium signaling disrupts olfactory signal transduction, leading to reduced receptor activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a direct inhibitor of Olfr872. It inhibits PI3K, impacting downstream signaling pathways and reducing the receptor's activity, ultimately impairing odorant detection. | ||||||
Xestospongin C | 88903-69-9 | sc-201505 | 50 µg | $500.00 | 14 | |
Xestospongin C indirectly inhibits Olfr872 by modulating inositol trisphosphate (IP3) receptor function. Altered IP3 signaling disrupts olfactory signal transduction, reducing receptor activity. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 directly inhibits Olfr872 by targeting P2X purinergic receptors. Inhibition of these receptors impairs olfactory signal transduction, leading to decreased receptor activity and odorant perception. | ||||||