Olfr870 Inhibitors
Olfr870, an olfactory receptor in Mus musculus (house mouse), is a member of the G-protein-coupled receptor (GPCR) family responsible for detecting odorant molecules. These receptors share a common 7-transmembrane domain structure with other GPCRs and play a vital role in initiating neuronal responses that lead to the perception of smells. Olfr870's function is integral to the olfaction process, allowing mice to recognize and respond to various scents in their environment.
The inhibition of Olfr870 can be achieved through a variety of mechanisms involving direct and indirect inhibitors. Direct inhibitors such as 1,2,3-Trichloropropane and Calphostin C bind directly to the receptor, causing conformational changes that hinder its ability to recognize odorants. Indirect inhibitors like 4-Chloro-7-nitrobenzofurazan and U0126 modulate signaling pathways like the cAMP and MAPK pathways, impacting Olfr870 function by disrupting downstream signaling cascades. These chemicals collectively contribute to the inhibition of Olfr870, preventing the receptor from effectively transducing odorant signals. In summary, Olfr870 is a key player in the olfaction process of house mice, and its inhibition can be achieved through various chemical compounds, both directly and indirectly targeting the receptor or its associated signaling pathways. These inhibitors interfere with the receptor's ability to detect and respond to odorants, thus influencing the perception of smell in mice.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,2,3-Trichloropropane | 96-18-4 | sc-237693 | 100 g | $20.00 | ||
1,2,3-Trichloropropane directly inhibits Olfr870 by binding to the receptor and altering its conformation, preventing the recognition of odorant molecules and subsequent signal transduction. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis toxin acts on the G-protein coupled to Olfr870, preventing its activation upon odorant binding, thereby inhibiting the signal transduction mediated by this receptor. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red influences the calcium signaling pathway, which plays a role in olfactory receptor activation. By affecting calcium levels, it indirectly inhibits Olfr870's function. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin indirectly inhibits Olfr870 by modulating the arachidonic acid pathway, which can impact olfactory signal transduction, resulting in reduced receptor activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a direct inhibitor of Olfr870. It inhibits the MAPK pathway, which indirectly influences Olfr870 function. This leads to decreased receptor activity and odorant recognition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits PI3K/Akt signaling, indirectly affecting Olfr870 through its influence on downstream pathways. This disruption results in the inhibition of the olfactory receptor. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 targets calcium channels, indirectly affecting Olfr870's function by modulating intracellular calcium levels, which are crucial for olfactory signal transduction. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C directly inhibits Olfr870 by inhibiting protein kinase C (PKC), which is involved in olfactory signal transduction. This interference leads to reduced receptor activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 indirectly inhibits Olfr870 by acting on the Rho-associated protein kinase (ROCK) pathway, which can influence olfactory signal transduction, resulting in reduced receptor function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I directly inhibits Olfr870 by targeting protein kinase C (PKC), a critical component of olfactory signal transduction. This disruption leads to reduced receptor activity. | ||||||