Olfr828 Activators
Olfr828 is an olfactory receptor gene encoding a protein that is a member of the G protein-coupled receptor (GPCR) family, specifically involved in the detection of odorous compounds. These receptors are crucial components of the olfactory system, which is responsible for the sense of smell. The primary function of Olfr828, as with other olfactory receptors, is to detect and respond to specific odorant molecules, translating these chemical signals into a form that can be interpreted by the brain. Activation of Olfr828 involves the direct binding of odorant molecules to the receptor, a process that is highly specific and dependent on the molecular structure of both the receptor and the odorant. Upon binding of an odorant, Olfr828 undergoes a conformational change that activates the associated G protein, leading to a cascade of intracellular signaling events. This typically involves the activation of adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels triggers the opening of cation channels, resulting in an influx of calcium and sodium ions, which generates an electrical signal. This signal is transmitted to the olfactory bulb in the brain, where it is processed and interpreted as a distinct smell.
The chemicals listed in the table are selected based on their potential to specifically and directly bind to and activate Olfr828. Their interaction with the receptor is essential for initiating the olfactory signaling pathway, which is crucial for the perception of odors. The specificity of these interactions underscores the diversity and complexity of the olfactory system, highlighting the intricate relationship between the chemical structure of odorants and the activation of specific olfactory receptors. The direct activation of Olfr828 by these chemicals demonstrates the intricate and selective nature of olfactory perception, a key aspect of the sensory experience of smell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Butyl acetate | 123-86-4 | sc-214637 sc-214637A | 1 ml 5 ml | $20.00 $79.00 | ||
Butyl acetate activates Olfr828 by directly binding to its ligand-binding domain, leading to a conformational change in the protein and the initiation of the olfactory signaling pathway. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate, known for its fruity, wine-like odor, activates Olfr828 by binding to the receptor's active site, triggering a conformational change and subsequent activation of the olfactory signal transduction pathway. | ||||||
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $29.00 | ||
Isovaleric acid, with its strong odor, activates Olfr828 by binding to the receptor. This direct interaction causes a conformational change in the receptor, leading to the initiation of olfactory signal transduction. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool, a terpene alcohol with a floral scent, activates Olfr828 by interacting directly with the receptor, causing a structural change and initiating the olfactory signaling pathway. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, an ester of salicylic acid, activates Olfr828 by fitting into its binding pocket. This interaction leads to the receptor's conformational change, triggering the olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene, a bicyclic monoterpene, activates Olfr828 through direct binding. Its molecular structure allows for effective interaction with the receptor, leading to activation and signal transduction in olfactory neurons. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, a phenolic aldehyde, can activate Olfr828 through direct interaction. This compound fits into the receptor's binding site, causing a structural change that leads to the activation of the olfactory signaling pathway. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, a ketone with a sweet smell, activates Olfr828 through direct binding. This interaction causes a conformational change in the receptor, leading to the initiation of a signaling pathway specific to olfactory receptors. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, an aldehyde with a grassy odor, activates Olfr828 by directly interacting with the receptor. Its molecular structure enables it to effectively bind to the receptor, initiating the olfactory signaling cascade. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a key component of lemongrass oil, can activate Olfr828 by directly interacting with the receptor site. Its molecular structure allows it to fit into the receptor, causing activation and subsequent signal transduction in the olfactory pathway. | ||||||