Olfr788 Activators
Olfr788, a member of the olfactory receptor family, plays a pivotal role in the mammalian olfactory system, which is responsible for detecting and distinguishing a wide range of odorant molecules in the environment. Situated within olfactory sensory neurons of the nasal epithelium, Olfr788 is a vital component that contributes to our sense of smell. The activation of Olfr788 involves a combination of direct and indirect mechanisms. Direct activators, such as 2-Heptanone and Benzyl Acetate, engage with the receptor directly, inducing conformational changes that initiate intracellular signaling cascades. These direct interactions amplify olfactory responses by enhancing the sensitivity of olfactory sensory neurons to odorant stimuli.
Indirect activators, exemplified by Forskolin and Y-27632, modulate specific cellular pathways to up-regulate Olfr788 activity. Forskolin activates adenylyl cyclase, leading to elevated intracellular cyclic AMP (cAMP) levels, which amplify receptor activation and olfactory signal transduction. Y-27632 inhibits Rho-associated protein kinase (ROCK), promoting olfactory neuron growth and heightening Olfr788 function. In conclusion, Olfr788 is a crucial component of the olfactory system, enabling organisms to detect and discriminate various odorant molecules in their surroundings. Its activation involves both direct and indirect mechanisms, ensuring the sensitivity and responsiveness of olfactory sensory neurons to environmental scents.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Heptanone | 110-43-0 | sc-238060 | 1 ml | $94.00 | ||
2-Heptanone directly activates Olfr788 by binding to the receptor, initiating downstream signaling events that amplify olfactory responses. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly enhances Olfr788 activity by depleting intracellular calcium stores, triggering calcium-dependent signaling cascades that activate the receptor. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
Benzyl Acetate directly stimulates Olfr788 by binding to the receptor, initiating a series of intracellular events that amplify receptor signaling and olfactory responses. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 indirectly promotes Olfr788 activity by inhibiting Rho-associated protein kinase (ROCK), enhancing olfactory neuron growth, and heightening receptor function. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin directly activates Olfr788 by binding to the receptor, initiating intracellular events that amplify receptor signaling, leading to enhanced olfactory responses. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine indirectly up-regulates Olfr788 by inhibiting L-type calcium channels, leading to increased intracellular calcium levels and enhanced receptor activity. | ||||||
Methyl benzoate | 93-58-3 | sc-215338 sc-215338A | 25 g 500 g | $23.00 $33.00 | ||
Methyl Benzoate directly stimulates Olfr788 by binding to the receptor, initiating a cascade of intracellular events that amplify receptor signaling and olfactory responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol indirectly promotes Olfr788 activity by activating SIRT1, modulating intracellular pathways that positively regulate Olfr788 expression and function. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol directly stimulates Olfr788 by binding to the receptor, initiating intracellular events that amplify receptor signaling, leading to enhanced olfactory responses. | ||||||