Olfr73 Inhibitors
Olfr73, a member of the olfactory receptor family 5 subfamily D (OR5D), is a crucial component of the olfactory system in Mus musculus (house mouse). It plays a pivotal role in the initiation of neuronal responses that lead to the perception of various odors. Olfr73, like other olfactory receptors, belongs to the extensive family of G-protein-coupled receptors (GPCRs) characterized by a common 7-transmembrane domain structure, shared with numerous neurotransmitter and hormone receptors. The primary function of Olfr73 is to interact with odorant molecules present in the nasal cavity, initiating a cascade of events that ultimately result in the perception of specific smells. Inhibition of Olfr73 can be achieved through various mechanisms, including both direct and indirect methods. Direct inhibitors, such as Citral and Camphor, interact directly with the receptor, preventing the binding of specific odorant molecules. Indirect inhibitors, such as SKF 96365 and Lovastatin, influence cellular processes and signaling pathways that indirectly affect Olfr73's functionality. For example, SKF 96365 blocks transient receptor potential (TRP) channels, affecting calcium influx and potentially modulating Olfr73's responses to odorants through alterations in intracellular calcium levels.
In conclusion, Olfr73 plays a fundamental role in the sensory perception of odors in house mice. The inhibition of Olfr73 can be achieved through various chemical compounds, each with its unique mechanism of action. These inhibitors provide valuable insights into the intricate processes involved in olfactory perception, shedding light on the underlying physiological mechanisms of sensory perception in rodents.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is a direct inhibitor that interacts with Olfr73, preventing the binding of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of citrus-like scents. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF 96365 is an indirect inhibitor that blocks transient receptor potential (TRP) channels, affecting calcium influx and potentially modulating Olfr73's responses to odorants through alterations in intracellular calcium levels. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is an indirect inhibitor that stabilizes F-actin filaments, influencing the cytoskeletal structure and indirectly affecting Olfr73 by altering the organization of cellular components involved in receptor function and odorant perception. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an indirect inhibitor that blocks calmodulin-dependent protein kinase II (CaMKII), influencing calcium-dependent signaling pathways and potentially modulating Olfr73's responses to odorants. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin is an indirect inhibitor that disrupts the mevalonate pathway, influencing cholesterol biosynthesis. This disruption indirectly affects Olfr73 by altering membrane composition, which can impact receptor function and odorant perception. | ||||||
Haloperidol | 52-86-8 | sc-507512 | 5 g | $190.00 | ||
Dopamine receptor antagonists act indirectly on dopaminergic signaling pathways, potentially modulating Olfr73's responses to odorants through cross-talk with dopamine-related cascades. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an indirect inhibitor that interferes with intracellular calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. This disruption indirectly influences Olfr73 by altering calcium-dependent signaling pathways, potentially affecting odorant perception. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that blocks beta-adrenergic receptors, influencing neuronal responses and potentially modulating Olfr73's function in perceiving odorants. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an indirect inhibitor that disrupts actin polymerization and cellular structure. This disruption indirectly influences Olfr73 by altering the organization of cellular components involved in receptor function, potentially impacting odorant perception. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin is a direct inhibitor that interacts with Olfr73, blocking the binding of odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of vanilla-like scents. | ||||||