Olfr61 Activators
Olfr61 is a member of the olfactory receptor family, specifically classified as a G-protein coupled receptor (GPCR). These receptors play a crucial role in the detection of odorants, translating chemical stimuli into neuronal signals. The functional aspect of Olfr61, like other olfactory receptors, is to detect specific odorant molecules and initiate a signal transduction cascade that ultimately results in the perception of smell. The activation of Olfr61 involves the binding of specific odorant molecules to the receptor, which leads to a conformational change in the receptor's structure. This change is crucial as it triggers the activation of associated G-proteins, which in turn initiate a series of intracellular events.
The general mechanism of activation for Olfr61, as for other GPCRs, involves several key steps. Upon binding of an odorant molecule to Olfr61, there is a conformational shift in the receptor, exposing sites that interact with G-proteins. This interaction causes the G-proteins to exchange GDP for GTP, thereby becoming activated. The activated G-proteins then dissociate into their alpha and beta-gamma subunits. These subunits interact with various effector proteins, leading to the generation of second messengers such as cyclic AMP (cAMP). The increase in cAMP levels within the olfactory sensory neurons leads to a cascade of further biochemical reactions, ultimately resulting in the generation of an electrical signal that is transmitted to the brain. This signal transduction pathway is a hallmark of GPCR activation and is critical for the conversion of a chemical odorant signal into a form that can be processed by the nervous system. The specificity of Olfr61 to certain odorant molecules and its role in the broader context of olfactory perception highlight the complex and finely tuned nature of the olfactory system. The activation of Olfr61 and similar receptors is a key step in the intricate process of smell perception, contributing to the diversity and richness of olfactory experiences.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate directly interacts with Olfr61, a G-protein coupled receptor (GPCR) involved in odor detection. This interaction causes a conformational change in Olfr61, leading to its activation. The activation mechanism involves the binding of the chemical to the ligand-binding domain of Olfr61, triggering G-protein signaling cascades. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr61 by binding to its odorant-binding site, inducing an allosteric change. This activation initiates a signal transduction pathway via G-proteins, resulting in the production of secondary messengers like cAMP, which further propagate the activation signal within the olfactory sensory neurons. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, upon binding to Olfr61, activates the receptor. This activation leads to the interaction of Olfr61 with G-proteins, subsequently triggering intracellular signaling pathways. The activation process involves the generation of intracellular messengers that amplify the olfactory signal. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene activates Olfr61 through direct interaction with the receptor's binding site. This interaction induces a conformational shift in Olfr61, triggering the activation of G-protein mediated signaling pathways. This results in an increased production of secondary messengers, amplifying the olfactory response. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr61 by directly interacting with the receptor's binding domain. This interaction prompts a conformational change in Olfr61, facilitating the activation of G-proteins. The activated G-proteins then trigger downstream signaling pathways, enhancing the olfactory signal transduction. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral's interaction with Olfr61 activates the receptor. This activation involves the binding of citral to Olfr61, leading to a conformational alteration and subsequent activation of G-protein signaling pathways. The process amplifies olfactory signals through the production of secondary messengers. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal activates Olfr61 by binding to its specific receptor site, inducing a structural change in the protein. This change triggers the activation of G-proteins and subsequent intracellular signaling pathways, enhancing the olfactory signal transduction related to green, grassy odors. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr61 through direct interaction with its binding site, leading to a conformational change in the receptor. This activation process triggers G-protein mediated signaling pathways, resulting in amplified olfactory signal transduction within the sensory neurons. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol binds to and activates Olfr61 by inducing a conformational change in the receptor. This activation triggers G-protein signaling cascades, leading to the production of secondary messengers and amplification of the sensory signal perceived as a spicy, clove-like odor. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr61 by directly interacting with the receptor, causing a change in its conformation. This leads to the activation of G-protein signaling pathways, amplifying the olfactory response through increased production of secondary messengers. | ||||||