Olfr523 Inhibitors
Olfr523, a member of the G protein-coupled receptor family, holds a pivotal role in the intricate process of olfactory signal transduction, contributing to the remarkable sensitivity and specificity exhibited by the sense of smell. Positioned on the membrane of olfactory sensory neurons, Olfr523 functions as a molecular gatekeeper, detecting and responding to specific odorants by initiating a cascade of intracellular events. Upon binding to odor molecules, Olfr523 triggers a series of signaling pathways that lead to the generation of neuronal signals, ultimately resulting in the perception of distinct smells. The receptor's functional significance lies in its ability to convert chemical stimuli into biological responses, thus playing a fundamental role in the intricate interplay of molecular events that underlie olfaction.
Inhibition of Olfr523 involves a nuanced array of mechanisms, reflecting the complexity of the signaling pathways and cellular processes associated with olfactory signal transduction. Direct inhibitors interfere with Olfr523 activation by targeting the receptor itself or disrupting essential cellular functions. For instance, compounds that inhibit topoisomerase I or protein kinase C disrupt the DNA unwinding process or interfere with phosphorylation events critical for olfactory signal transduction, leading to the inhibition of Olfr523. On the other hand, indirect inhibitors modulate intracellular signaling pathways associated with Olfr523, impacting olfactory receptor neuron function and hindering the normal activation process. These chemicals, such as those targeting the PI3K or p38 MAPK pathways, disrupt phosphorylation cascades and interfere with normal cellular dynamics, contributing to the suppression of Olfr523 activation. Understanding these intricate mechanisms provides valuable insights into the regulation of olfactory responses, advancing our comprehension of sensory biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
A topoisomerase I inhibitor, Camptothecin influences DNA topology, disrupting Olfr523 activation indirectly. By impeding the normal DNA unwinding process, it interferes with the transcriptional machinery involved in olfactory signal transduction, leading to the inhibition of Olfr523. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Targets the PI3K pathway to indirectly inhibit Olfr523. LY294002 modulates intracellular signaling, impacting olfactory receptor neuron function and hindering the activation of Olfr523. The inhibition is achieved by disrupting the phosphorylation cascades associated with PI3K signaling. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
An inhibitor of protein kinase C (PKC), Chelerythrine directly influences Olfr523 activation. By disrupting PKC-mediated signaling, it interferes with the normal phosphorylation events, leading to altered olfactory signal transduction and inhibition of Olfr523. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Modulates Olfr523 indirectly by targeting the PI3K pathway. Wortmannin modifies intracellular signaling, impacting olfactory receptor neuron function and hindering the activation of Olfr523. The inhibition is achieved through disruption of the phosphorylation cascades associated with PI3K signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Targets the p38 MAPK pathway to indirectly inhibit Olfr523. SB203580 blocks phosphorylation cascades, disrupting downstream signaling and suppressing olfactory signal transduction. The inhibition is achieved by interfering with the normal activation events associated with the p38 MAPK pathway. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
Indirectly inhibits Olfr523 by chelating intracellular calcium, modulating olfactory receptor neuron responses. BAPTA-AM alters the olfactory signal transduction process, leading to the suppression of Olfr523 activation. The inhibition is achieved through interference with intracellular calcium dynamics critical for olfactory signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inhibitor of endoplasmic reticulum (ER) Ca2+-ATPase, Thapsigargin directly affects Olfr523 activation. By disrupting ER calcium homeostasis, it interferes with the intracellular signaling required for normal olfactory signal transduction, leading to the inhibition of Olfr523. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Indirectly inhibits Olfr523 by targeting the extracellular signal-regulated kinase (ERK) pathway. PD98059 disrupts phosphorylation cascades, impacting olfactory receptor neuron function and suppressing the activation of Olfr523. The inhibition is achieved through interference with the normal activation events associated with the ERK pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Modulates Olfr523 indirectly by activating adenylate cyclase, influencing cAMP levels. Forskolin alters the olfactory signal transduction process, leading to the suppression of Olfr523 activation. The inhibition is achieved through modification of intracellular cAMP levels critical for olfactory signal transduction. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Affects Olfr523 indirectly by disrupting the Golgi apparatus function. Brefeldin A interferes with intracellular vesicle trafficking, impacting the normal localization of olfactory signal transduction components and suppressing the activation of Olfr523. The inhibition is achieved through interference with the vesicular dynamics critical for olfactory signal transduction. | ||||||