Olfr477 Inhibitors
Olfr477, an olfactory receptor, plays a pivotal role in detecting specific odorants, initiating signal transduction pathways in olfactory sensory neurons. This receptor is intricately involved in olfactory perception, contributing to the intricate network of olfactory signal processing. The olfactory transduction cascade activated by Olfr477 involves complex interactions with various signaling pathways, including MAPK, PI3K, JNK, NF-κB, and AMPK.
The inhibition of Olfr477 can be achieved through direct or indirect means, focusing on disrupting these crucial signaling pathways. Compounds such as TAK-875, SB-203580, and U0126 indirectly influence Olfr477 by targeting GPR40, p38 MAPK, and MEK1/2, respectively, perturbing the downstream events crucial for olfactory signal transduction. Wortmannin and LY294002, as PI3K inhibitors, interfere with olfactory sensory neuron responses, affecting the activation of Olfr477. Similarly, SP600125, GW9662, PD98059, BAY 11-7082, A769662, CHIR-99021, and KN-62 act as indirect inhibitors by targeting JNK, PPARγ, MEK1, NF-κB, AMPK, GSK-3, and CaMKII pathways, respectively. In conclusion, understanding the intricate molecular interactions and signaling pathways associated with Olfr477 provides valuable insights into the development of inhibitors that can modulate olfactory perception. The identified chemicals, through their specific actions on these pathways, present potential avenues for further exploration in the context of olfactory receptor inhibition.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580, a p38 MAPK inhibitor, indirectly interferes with Olfr477 function. By blocking p38 MAPK, it disrupts the associated signaling cascade, affecting olfactory sensory neuron activation and subsequently impeding Olfr477 signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126, a MEK1/2 inhibitor, exerts indirect inhibition on Olfr477. Its action on the MAPK pathway interrupts the signal transduction cascade, modulating olfactory receptor responses and impairing the downstream activation of Olfr477. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, indirectly hinders Olfr477 activity. By inhibiting PI3K, it disrupts downstream signaling pathways involved in olfactory transduction, leading to diminished responsiveness of Olfr477. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly influences Olfr477 by perturbing PI3K-mediated signaling pathways. This disruption alters olfactory sensory neuron responses, attenuating the downstream activation of Olfr477. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, indirectly modulates Olfr477 function by targeting the JNK signaling pathway. Its interference with JNK signaling disrupts olfactory signal transduction, impairing the activation of Olfr477 downstream. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
GW9662, a PPARγ antagonist, indirectly inhibits Olfr477 by affecting PPARγ-regulated pathways. This modulation disrupts olfactory sensory neuron responses, leading to attenuation in the activation of Olfr477. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK1 inhibitor, indirectly influences Olfr477 by targeting the MAPK pathway. Its action disrupts olfactory signal transduction, affecting the downstream activation of Olfr477. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082, an NF-κB inhibitor, indirectly hinders Olfr477 activity by modulating NF-κB signaling. This modulation disrupts olfactory sensory neuron responses, leading to attenuation in the activation of Olfr477. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMPK activator, indirectly influences Olfr477 by modulating AMPK-mediated pathways. Its action disrupts olfactory signal transduction, affecting the downstream activation of Olfr477. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3 Inhibitor XVI indirectly inhibits Olfr477 by targeting the GSK-3 pathway. Its action disrupts olfactory signal transduction, affecting the downstream activation of Olfr477. | ||||||