Olfr474 Inhibitors
Olfr474, a prominent member of the olfactory receptor family, plays a pivotal role in initiating neuronal responses that underlie the perception of various odors. As a G-protein-coupled receptor (GPCR) with a 7-transmembrane domain structure, Olfr474 shares structural characteristics with neurotransmitter and hormone receptors. Its primary function involves the recognition and G protein-mediated transduction of odorant signals within the nasal cavity, contributing significantly to the intricate world of olfactory experiences.
The inhibition of Olfr474 involves the orchestrated interplay of various chemical inhibitors targeting specific cellular pathways essential for olfactory signal transduction. Atropine, SP600125, Wortmannin, U0126, LY294002, KN-93, SB-203580, Dantrolene, Brefeldin A, H-89, Bisindolylmaleimide I, and PD 98059 collectively contribute to Olfr474 inhibition through their respective mechanisms. These inhibitors directly or indirectly impact processes such as muscarinic receptor activity, JNK and PI3K-dependent events, MEK-mediated MAPK pathway, CaMKII and PKA activities, ryanodine receptor function, vesicle trafficking, and PKC-dependent processes. These disruptions impair the receptor's ability to initiate a neuronal response and perceive odors effectively. In conclusion, the intricate mechanisms of Olfr474 inhibition reveal the depth of understanding required to decipher the complexities of olfactory receptor function. Exploring these pathways provides valuable insights into the molecular intricacies governing the perception of diverse odors mediated by Olfr474 in this organism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atropine | 51-55-8 | sc-252392 | 5 g | $200.00 | 2 | |
Atropine, a muscarinic acetylcholine receptor antagonist, directly inhibits Olfr474 by binding to muscarinic receptors. This disrupts G protein-mediated signal transduction, hindering the recognition and transduction of odorant signals within the olfactory system. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), SP600125 indirectly inhibits Olfr474 by disrupting the JNK signaling pathway. This interference impacts G protein-mediated transduction of odorant signals, altering the receptor's ability to initiate a neuronal response and perceive odors effectively. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, directly influences intracellular signaling pathways crucial for Olfr474 function. By disrupting PI3K-dependent events, this chemical inhibits Olfr474, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
A selective MEK inhibitor, U0126 disrupts the MAPK pathway. This compound indirectly inhibits Olfr474 by interfering with MAPK-dependent events, negatively impacting G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinase (PI3K) inhibitor, LY294002 influences intracellular signaling pathways crucial for Olfr474 function. By disrupting PI3K-dependent events, this chemical indirectly inhibits Olfr474, impairing the normal transduction of odorant signals and negatively impacting G protein-mediated responses of the olfactory receptor. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
A CaMKII inhibitor, KN-93 modulates CaMKII-dependent processes in olfactory signal transduction. This chemical indirectly inhibits Olfr474 by interfering with calcium-calmodulin-dependent kinase II (CaMKII), disrupting downstream events crucial for G protein-mediated transduction of odorant signals. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
An inhibitor of p38 mitogen-activated protein kinase (MAPK), SB-203580 indirectly inhibits Olfr474 by disrupting the p38 MAPK pathway. This disruption negatively impacts G protein-mediated transduction of odorant signals, altering the receptor's ability to initiate a neuronal response and perceive odors effectively. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene, a ryanodine receptor antagonist, indirectly inhibits Olfr474 by disrupting calcium-dependent processes. This disruption affects the intracellular calcium levels crucial for olfactory signal transduction, impairing the recognition and transduction of odorant signals by Olfr474 within the nasal cavity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of vesicle trafficking, Brefeldin A disrupts Golgi apparatus function and indirectly inhibits Olfr474. This disruption affects the proper localization and functioning of olfactory receptors, impairing the recognition and transduction of odorant signals within the nasal cavity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059, a selective MEK inhibitor, disrupts the MAPK pathway. This compound indirectly inhibits Olfr474 by interfering with MAPK-dependent events, negatively impacting G protein-mediated transduction of odorant signals. The disruption occurs at the level of MEK, influencing downstream events crucial for olfactory perception. | ||||||