Olfr457 Activators
Chemical activators of Olfr457, such as Octanal, Nonanal, and Decanal, function by directly interacting with the ligand-binding domain of the protein. These chemicals induce conformational changes in Olfr457, crucial for activating the G-protein coupled receptor (GPCR) pathway. The binding of these activators to Olfr457 results in the stimulation of adenylate cyclase, subsequently elevating intracellular cyclic AMP (cAMP) levels. This increase in cAMP activates protein kinase A (PKA) and other downstream signaling molecules, leading to various cellular responses.
A diverse range of chemicals, including Linalyl acetate, Myrcene, and Nerol, share a common mechanism of activating Olfr457. They bind to specific sites on the protein, initiating a cascade of intracellular events. This binding not only alters the protein conformation but also effectively triggers the GPCR pathway. The activation of this pathway leads to a series of intracellular reactions, primarily the production of cAMP. This signaling molecule plays a central role in activating downstream effectors, thus propagating the signal initiated by the chemical activators. The downstream effects of these signaling pathways culminate in physiological responses, illustrating the direct impact these chemical activators have on the functional activity of Olfr457.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr457 by directly binding to its ligand-binding domain. This interaction causes a conformational change in Olfr457, initiating signal transduction through G-protein coupled receptors, leading to increased intracellular cAMP levels and subsequent cellular responses. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $67.00 | ||
Nonanal serves as a direct activator of Olfr457 by interacting with its specific odorant binding site. This binding induces allosteric modulation of Olfr457, activating adenylate cyclase via G-protein signaling, thus elevating cAMP and initiating downstream cellular effects. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal activates Olfr457 by directly binding to its odorant recognition site, promoting the activation of the G-protein coupled receptor pathway, increasing cAMP production, and activating protein kinase A, leading to signal transduction processes. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol activates Olfr457 by directly interacting with its ligand-binding site, inducing a conformational change that facilitates the activation of the G-protein coupled receptor pathway, increasing cAMP, and activating subsequent signaling mechanisms. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
(±)-β-Citronellol acts as a direct activator of Olfr457 by engaging with its odorant binding site. This interaction prompts a conformational change, activating G-protein signaling cascades, leading to elevated levels of cAMP and activation of downstream cellular pathways. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr457 by interacting with its specific odorant binding domain, facilitating the activation of G-protein coupled receptor pathways, increasing cAMP levels, and activating downstream signaling pathways, including protein kinase A activation. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral directly activates Olfr457 by binding to its ligand recognition site, triggering a conformational change that leads to G-protein signaling pathways activation, an increase in intracellular cAMP levels, and subsequent activation of downstream cellular responses. | ||||||
(−)-Carvone | 6485-40-1 | sc-293985 sc-293985A | 25 ml 500 ml | $51.00 $230.00 | 2 | |
(-)-Carvone activates Olfr457 by binding to its specific ligand-binding domain, facilitating the activation of G-protein coupled receptor mechanisms, leading to the elevation of cAMP levels, and triggering a cascade of intracellular signaling pathways and cellular responses. | ||||||
Farnesol | 4602-84-0 | sc-204748 sc-204748A | 50 ml 100 ml | $281.00 $374.00 | 2 | |
Farnesol activates Olfr457 through direct interaction with its odorant recognition site, initiating a signaling cascade through G-protein activation, promoting an increase in cAMP levels, and leading to the activation of downstream signaling pathways and physiological responses. | ||||||